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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Decaffeinated green tea extract rich in epigallocatechin-3-gallate improves insulin resistance and metabolic profiles in normolipidic diet-but not high-fat diet-fed mice

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Santana, Aline [1] ; Santamarina, Aline [1] ; Souza, Gabriel [2] ; Mennitti, Lais [3] ; Okuda, Marcos [1] ; Venancio, Daniel [4] ; Seelaender, Marilia [5] ; do Nascimento, Claudia Oiler [1] ; Ribeiro, Eliane [1] ; Lira, Fabio [6] ; Oyama, Lila [1]
Total Authors: 11
[1] Univ Fed Sao Paulo, Dept Fisiol, BR-04023062 Sao Paulo, SP - Brazil
[2] Univ Sao Judas Tadeu, Lab Movimento Humano, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Programa Posgrad Interdisciplinar Ciencias Saude, BR-04023062 Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Psicobiol, BR-04023062 Sao Paulo, SP - Brazil
[5] Univ Fed Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, BR-04023062 Sao Paulo, SP - Brazil
[6] Univ Estadual Paulista, Dept Phys Educ, Exercise & Immunometab Res Grp, Presidente Prudente, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF NUTRITIONAL BIOCHEMISTRY; v. 26, n. 9, p. 893-902, SEP 2015.
Web of Science Citations: 12

Supplementation with epigallocatechin-3-gallate (EGCG), which restores metabolic profiles, has been proposed as an option for preventing and treating obesity. We investigated whether decaffeinated green tea extract rich in EGCG, attenuates high-fat diet (HFD)-induced metabolic alterations in Swiss mice. The mice were maintained on either a control diet (CD) or HFD for 8 weeks and supplemented with either a placebo or EGCG (50 mg/kg/day). Body weight, serum lipid profiles, cytokine protein expression, and content in epididymal (EPI) and retroperitoneal (RET) adipose tissues, and adipocyte area were measured. The body weights of HFD + placebo-fed mice were increased compared with those of HFD + EGCG-fed mice (28 and 21%, respectively), whereas the body weights of CD + EGCG-fed mice were decreased 16% compared with those of the CD + placebo group. Serum triglyceride levels were decreased 32% in the CD + EGCG group compared with the CD + placebo group. Compared with the CD + placebo group, increased phosphorylation of AMPK and hormone-sensitive lipase in EPI and RET, respectively, was found in the CD + EGCG group. Increased acetyl-CoA carboxylase phosphorylation was observed in both adipose tissues. In addition, TNF-alpha and IL-10 levels in EPI and adiponectin levels were higher in the CD + EGCG group than in the CD + placebo group. TNF-alpha levels were lower in the HFD + EGCG group than in the HFD + placebo group. Furthermore, the CD + EGCG group exhibited a lower adipocyte area than the CD + placebo group. These indicate that the effects of decaffeinated green tea extract on body mass may be related to the crosstalk between lipolytic and inflammatory pathways in normolipidic diet-fed mice but not in HFD-fed mice. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/03713-5 - Effect of green tea extract rich in epigalocatechin-galate intake on citokines and metabolic regulators in adipose tissue and esqueletic muscle in obese mice induced by hyperlilipidic diet
Grantee:Lila Missae Oyama
Support Opportunities: Regular Research Grants