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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Baroreflex activation in conscious rats modulates the joint inflammatory response via sympathetic function

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Author(s):
Bassi, Gabriel S. [1] ; Brognara, Fernanda [2] ; Castania, Jaci A. [2] ; Talbot, Jhimmy [3] ; Cunha, Thiago M. [3, 1] ; Cunha, Fernando Q. [3, 1] ; Ulloa, Luis [4] ; Kanashiro, Alexandre [3] ; Martins Dias, Daniel P. [2] ; Salgado, Helio C. [2]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Immunol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, Med Sch Ribeirao Preto, Dept Pharmacol, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Rutgers State Univ, New Jersey Med Sch, Newark, NJ 07103 - USA
Total Affiliations: 4
Document type: Journal article
Source: BRAIN BEHAVIOR AND IMMUNITY; v. 49, p. 140-147, OCT 2015.
Web of Science Citations: 16
Abstract

The baroreflex is a critical physiological mechanism controlling cardiovascular function by modulating both the sympathetic and parasympathetic activities. Here, we report that electrical activation of the baroreflex attenuates joint inflammation in experimental arthritis induced by the administration of zymosan into the femorotibial cavity. Baroreflex activation combined with lumbar sympathectomy, adrenalectomy, celiac subdiaphragmatic vagotomy or splenectomy dissected the mechanisms involved in the inflammatory modulation, highlighting the role played by sympathetic inhibition in the attenuation of joint inflammation. From the immunological standpoint, baroreflex activation attenuates neutrophil migration and the synovial levels of inflammatory cytokines including TNF, and IL-1 beta, but does not affect the levels of the anti-inflammatory cytokine IL-10. The anti-inflammatory effects of the baroreflex system are not mediated by IL-10, the vagus nerve, adrenal glands or the spleen, but by the inhibition of the sympathetic drive to the knee. These results reveal a novel physiological neuronal network controlling peripheral local inflammation. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 11/20343-4 - Antiinflammatory cholinergic pathway: the role of neuroimmunomodulation in the control of inflammatory response
Grantee:Alexandre Kanashiro
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
Grantee:Fernando de Queiroz Cunha
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 14/15386-4 - Modulation of the inflammatory response to LPS by electrical activation of the baroreflex in conscious rats
Grantee:Fernanda Brognara Penteado Dias
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/20549-7 - New insights in cardiovascular regulation under physiological and pathophysiological condition
Grantee:Helio Cesar Salgado
Support type: Research Projects - Thematic Grants
FAPESP's process: 12/04237-2 - Antiinflammatory cholinergic pathway: the role of neuroimmunomodulation in the control of inflammatory response
Grantee:Alexandre Kanashiro
Support type: Scholarships in Brazil - Young Researchers