ADAM10 gene expression in the blood cells of Alzhe... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

ADAM10 gene expression in the blood cells of Alzheimer's disease patients and mild cognitive impairment subjects

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Author(s):
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Manzine, Patricia Regina [1] ; Marcello, Elena [2] ; Borroni, Barbara [3] ; Kamphuis, Willem [4] ; Hol, Elly [4, 5, 6] ; Padovani, Alessandro [3] ; Nascimento, Carla Crispim [1] ; Bueno, Patricia de Godoy [7] ; Carvalho Vale, Francisco Assis [8] ; Pavarini, Sofia Cristina Lost [1] ; Di Luca, Monica [2] ; Cominetti, Marcia Regina [1]
Total Authors: 12
Affiliation:
[1] Univ Fed Sao Carlos, Dept Gerontol, BR-13565905 Sao Carlos, SP - Brazil
[2] Univ Milan, Dept Pharmacol & Biomol Sci, Milan - Italy
[3] Univ Brescia, Dept Clin & Expt Sci, Neurol Unit, Brescia - Italy
[4] Netherlands Inst Neurosci, Amsterdam - Netherlands
[5] Univ Amsterdam, Ctr Neurosci, Swammerdam Inst Life Sci, Amsterdam - Netherlands
[6] Univ Med Ctr Utrecht, Brain Ctr Rudolf Magnus, Dept Translat Neurosci, Utrecht - Netherlands
[7] Univ Fed Sao Carlos, Dept Physiol Sci, BR-13565905 Sao Carlos, SP - Brazil
[8] Univ Fed Sao Carlos, Dept Med, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Source: BIOMARKERS; v. 20, n. 3, p. 196-201, 2015.
Web of Science Citations: 13
Abstract

ADAM10 is a potential biomarker for Alzheimer's disease (AD). ADAM10 protein levels are reduced in platelets of AD patients. The aim was to verify the total blood and platelet ADAM10 gene expression in AD patients and to compare with mild cognitive impairment (MCI) and healthy subjects. No significant differences in ADAM10 gene expression were observed. Therefore, the decrease of ADAM10 protein in platelets of AD patients is not caused by a reduction in ADAM10 mRNA. Further studies must be performed to investigate other pathways in the down regulation of ADAM10 protein. (AU)

FAPESP's process: 13/06879-4 - Blood biomarkers for Alzheimer's Disease: evaluation of ADAM10 gene expression and microRNAs
Grantee:Márcia Regina Cominetti
Support Opportunities: Regular Research Grants
FAPESP's process: 10/09497-7 - Platelet levels of ADAM10 in tracking Alzheimer's disease: contributions for nursing care
Grantee:Sofia Cristina Iost Pavarini
Support Opportunities: Regular Research Grants
FAPESP's process: 12/08654-7 - Blood biomarkers for Alzheimer's Disease: evaluation of ADAM10 gene expression and micro-RNAs
Grantee:Patricia Regina Manzine Moralles
Support Opportunities: Scholarships in Brazil - Doctorate