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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Extracellular Vesicles: Role in Inflammatory Responses and Potential Uses in Vaccination in Cancer and Infectious Diseases

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Author(s):
Campos, Joao Henrique [1] ; Soares, Rodrigo Pedro [2] ; Ribeiro, Kleber [1] ; Andrade, Andre Cronemberger [1] ; Batista, Wagner Luiz [1] ; Torrecilhas, Ana Claudia [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo UNIFESP, Dept Ciencias Biol, Lab Imunol Celular & Bioquim Fungos & Protozoario, BR-09913030 Sao Paulo, SP - Brazil
[2] Fundacao Oswaldo Cruz, Lab Parasitol Celular & Mol, Ctr Pesquisas Rene Rachou, BR-30190002 Belo Horizonte, MG - Brazil
Total Affiliations: 2
Document type: Review article
Source: CLINICAL & DEVELOPMENTAL IMMUNOLOGY; 2015.
Web of Science Citations: 19
Abstract

Almost all cells and organisms release membrane structures containing proteins, lipids, and nucleic acids called extracellular vesicles (EVs), which have a wide range of functions concerning intercellular communication and signaling events. Recently, the characterization and understanding of their biological role have become a main research area due to their potential role in vaccination, as biomarkers antigens, early diagnostic tools, and therapeutic applications. Here, we will overview the recent advances and studies of Evs shed by tumor cells, bacteria, parasites, and fungi, focusing on their inflammatory role and their potential use in vaccination and diagnostic of cancer and infectious diseases. (AU)

FAPESP's process: 14/13961-1 - Role of secreted aspartyl protease (PbSAP) in virulence and dimorphism in the pathogenic fungus Paracoccidioides brasiliensis
Grantee:Wagner Luiz Batista
Support type: Regular Research Grants