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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Stimuli-Responsive Nanoparticles for siRNA Delivery

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Author(s):
Eloy, Josimar O. [1, 2] ; Petrilli, Raquel [2, 1] ; Lopez, Renata F. V. [1] ; Lee, Robert J. [2]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Coll Pharmaceut Sci, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Ohio State Univ, Coll Pharm, Columbus, OH 43210 - USA
Total Affiliations: 2
Document type: Journal article
Source: CURRENT PHARMACEUTICAL DESIGN; v. 21, n. 29, p. 4131-4144, 2015.
Web of Science Citations: 10
Abstract

Nanoparticles have been extensively employed to deliver many drugs, including siRNA, for the treatment of a variety of diseases, particularly cancer. Lately, there has been a great deal of effort to design nanoparticles with materials that are able to respond to intrinsic or extrinsic stimuli for ``on demand{''} delivery of siRNA. These nanoparticles are able to trigger siRNA release upon different stimuli, such as a pH decrease, redox gradient, enzyme, light, magnetic field, temperature, ultrasound or electric current. Frequently, the stimuli cause the nanoparticles to undergo protonation, hydrolytic breakdown or phase transition for triggered release of siRNA, resulting in decreased side effects and better therapeutic outcome. While studies have demonstrated efficient in vitro and in vivo delivery, these ``smart{''} nanoparticles have not yet reached the clinic. In this review, we address different classes of nanoparticles, such as polyplexes, lipoplexes, liposomes, polymeric micelles, polymeric, lipid and inorganic nanoparticles, that are able to respond to specific stimuli for siRNA triggered-release, emphasizing their application and discussing the latest advances. (AU)

FAPESP's process: 13/05362-8 - Functionalization of liposomes containing metformin and paclitaxel with trastuzumab: development, characterization and evaluation of efficacy against breast cancer
Grantee:Josimar de Oliveira Eloy
Support type: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 12/23764-3 - Topical application of liposomes containing cetuximab: the effect of physical skin penetration enhancement techniques for cutaneous squamous cell carcinoma
Grantee:Raquel Petrilli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/10388-3 - Liposomes and immunoliposomes containing anticancer drugs: development, characterization and efficacy evaluation against breast cancer
Grantee:Josimar de Oliveira Eloy
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/15134-2 - Preparation of immunoliposomes for topical skin cancer treatment
Grantee:Raquel Petrilli
Support type: Scholarships abroad - Research Internship - Doctorate