Exploiting novel process windows for the synthesis of meso-substituted porphyrins under continuous flow conditions

Author(s)

Momo, Patricia B. ^[1] ; Bellete, Barbara S. ^[1] ; Brocksom, Timothy J. ^[1] ; de Souza, Rodrigo O. M. A. ^[2] ; de Oliveira, Kleber T. ^[1]

Affiliation

^[1] Univ Fed Sao Carlos, Dept Quim, BR-13565905 Sao Carlos, SP - Brazil

^[2] Univ Fed Rio de Janeiro, Inst Quim, BR-22941909 Rio De Janeiro - Brazil

• Document type: Journal article
• Source: RSC ADVANCES; v. 5, n. 102, p. 84350-84355, 2015.
• Web of Science Citations: 11

Abstract

Porphyrin synthesis by classical methods frequently involves the use of high temperatures, toxic and dangerous reagents yielding the product in very low amounts and with poor scalability. Herein, we have studied the synthesis of meso-substituted porphyrins under continuous flow conditions, thus demonstrating scale-up for the porphyrin synthesis in a safe, cost-competitive, highly pure, reproducible and robust manner. (AU)

• FAPESP's process: 13/06532-4 - Cross-coupling reactions on the synthesis of new photosensitizers with high conjugation
• Grantee: Kleber Thiago de Oliveira
• Support type: Regular Research Grants
• FAPESP's process: 13/07276-1 - CEPOF - Optics and Photonic Research Center
• Grantee: Vanderlei Salvador Bagnato
• Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
• FAPESP's process: 11/13993-2 - Methodologies for the synthesis of bioactive terpenes
• Grantee: Timothy John Brocksom
• Support type: Regular Research Grants