New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Coinfected Patients

Author(s)

Papotto, Pedro Henrique ^[1] ; Maeda, Solange ^[2] ; Tomimori, Jane ^[2] ; Xavier, Marilia Brasil ^[3] ; Rizzo, Luiz Vicente ^[1] ; Kallas, Esper Georges ^[4] ; Carvalho, Karina Inacio ^[1]

Affiliation

^[1] Hosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Dermatol, Sao Paulo - Brazil

^[3] Fed Univ Para, Dept Dermatol, BR-66059 Belem, Para - Brazil

^[4] Univ Sao Paulo, Fac Med, Disciplina Imunol Clin & Alergia LIM60, Sao Paulo - Brazil

• Document type: Journal article
• Source: PLoS Neglected Tropical Diseases; v. 9, n. 9 SEP 2015.
• Web of Science Citations: 1

Abstract

Leprosy control is achieved through a fine-tuning of T(H)1 and T(H)2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function. (AU)

• FAPESP's process: 13/15448-7 - Efficacy evaluation of murine selective CD28 antagonist, mPEG PV1-Fab', for the treatment of experimental autoimmune uveitis
• Grantee: Pedro Henrique Papotto Rosa
• Support Opportunities: Scholarships in Brazil - Master