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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New Players in the Same Old Game: Disturbance of Group 2 Innate Lymphoid Cells in HIV-1 and Mycobacterium leprae Coinfected Patients

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Papotto, Pedro Henrique [1] ; Maeda, Solange [2] ; Tomimori, Jane [2] ; Xavier, Marilia Brasil [3] ; Rizzo, Luiz Vicente [1] ; Kallas, Esper Georges [4] ; Carvalho, Karina Inacio [1]
Total Authors: 7
[1] Hosp Israelita Albert Einstein, Inst Israelita Ensino & Pesquisa, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Dermatol, Sao Paulo - Brazil
[3] Fed Univ Para, Dept Dermatol, BR-66059 Belem, Para - Brazil
[4] Univ Sao Paulo, Fac Med, Disciplina Imunol Clin & Alergia LIM60, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: PLoS Neglected Tropical Diseases; v. 9, n. 9 SEP 2015.
Web of Science Citations: 1

Leprosy control is achieved through a fine-tuning of T(H)1 and T(H)2 immune response pattern balance. Given the increasing epidemiological overlay of HIV and M. leprae infections, immune response in co-infected patients consists in an important contemporary issue. Here we describe for the first time the innate lymphoid cells compartment in peripheral blood of leprosy and HIV/M. leprae co-infected patients, and show that co-infection increases group 2 innate lymphoid whilst decreasing group 1 innate lymphoid cells frequencies and function. (AU)

FAPESP's process: 13/15448-7 - Efficacy evaluation of murine selective CD28 antagonist, mPEG PV1-Fab', for the treatment of experimental autoimmune uveitis.
Grantee:Pedro Henrique Papotto Rosa
Support type: Scholarships in Brazil - Master