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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Relationship among Short and Long Term of Hypoinsulinemia-Hyperglycemia, Dermatophytosis, and Immunobiology of Mononuclear Phagocytes

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Author(s):
Fraga-Silva, Thais F. C. [1, 2] ; Marchetti, Camila M. [1] ; Mimura, Luiza A. N. [2] ; Locachevic, Gisele A. [3] ; Golim, Marjorie A. [4] ; Venturini, James [1] ; Arruda, Maria S. P. [1]
Total Authors: 7
Affiliation:
[1] Univ Estadual Paulista UNESP, Sch Sci, Dept Biol Sci, BR-17033360 Bauru, SP - Brazil
[2] Univ Estadual Paulista UNESP, Inst Biosci Botucatu, Dept Microbiol & Immunol, BR-18618970 Botucatu, SP - Brazil
[3] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, BR-14040903 Ribeirao Preto, SP - Brazil
[4] Univ Estadual Paulista UNESP, Botucatu Blood Ctr, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Mediators of Inflammation; 2015.
Web of Science Citations: 3
Abstract

Dermatophytes are fungi responsible for causing superficial infections. In patients with diabetes mellitus (DM), dermatophytosis is usually more severe and recurrent. In the present study, we aimed to investigate the influence of short and long term hypoinsulinemia-hyperglycemia (HH) during experimental infection by Trichophyton mentagrophytes as well as alterations in the mononuclear phagocytes. Our results showed two distinct profiles of fungal outcome and immune response. Short term HH induced a discrete impaired proinflammatory response by peritoneal adherent cells (PAC) and a delayed fungal clearance. Moreover, long term HH mice showed low and persistent fungal load and a marked reduction in the production of TNF-alpha by PAC. Furthermore, while the inoculation of TM in non-HH mice triggered high influx of Gr1(+) monocytes into the peripheral blood, long term HH mice showed low percentage of these cells. Thus, our results demonstrate that the time of exposure of HH interferes with the TM infection outcome as well as the immunobiology of mononuclear phagocytes, including fresh monocyte recruitment from bone marrow and PAC activity. (AU)