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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Does occupational exposure to anesthetic gases lead to increase of pro-inflammatory cytokines?

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Author(s):
Chaoul, Mauricio Martins [1] ; Braz, Jose Reinaldo C. [1] ; Lucio, Lorena Mendes C. [1] ; Golim, Marjorie A. [2] ; Braz, Leandro Gobbo [1] ; Braz, Mariana Gobbo [1]
Total Authors: 6
Affiliation:
[1] UNESP Univ Estadual Paulista, Fac Med Botucatu, Dept Anestesiol, BR-18618970 Botucatu, SP - Brazil
[2] UNESP Univ Estadual Paulista, Fac Med Botucatu, Div Hemoctr, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Inflammation Research; v. 64, n. 12, p. 939-942, DEC 2015.
Web of Science Citations: 12
Abstract

Introduction There is great concern about the possible harmful effects of exposure to volatile anesthetics. The current study aimed at evaluating, for the first time, the effects of occupational exposure to anesthetic gases on physicians who work in operating rooms, by determining several inflammatory cytokines. Materials and methods Plasma inflammatory cytokines (IL-1 beta, -6, -8, -10, -12, TNF-alpha) were investigated in 30 individuals who were allocated into two groups of 15: the exposed group, consisting of operating room medical personnel exposed to a mixture of anesthetic gases for 3 years, and a control group composed of medical personnel not exposed to anesthetic gases. The concentrations of volatile anesthetics were measured in the operating room by means of an infrared portable analyzer Results and conclusions Our findings suggest an increase of the pro-inflammatory IL-8 (p < 0.05) in medical personnel exposed to high concentrations of anesthetic gases, even for a relatively short period. (AU)

FAPESP's process: 13/21130-0 - Correlation between concentration of waste anesthetic gases with oxidative stress and immune response in medical residents occupationally exposed
Grantee:Mariana Gobbo Braz
Support type: Regular Research Grants
FAPESP's process: 13/13115-0 - Assessment of inflammatory markers in medical residents exposed for three years to waste anesthetic gases
Grantee:Maurício Martins Chaoul
Support type: Scholarships in Brazil - Scientific Initiation