Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Square-Wave Voltammetric Determination of Paracetamol and Codeine in Pharmaceutical and Human Body Fluid Samples Using a Cathodically Pretreated Boron-Doped Diamond Electrode

Full text
Author(s):
Santos, Anderson M. [1] ; Vicentini, Fernando C. [1] ; Deroco, Patricia B. [1] ; Rocha-Filho, Romeu C. [1] ; Fatibello-Filho, Orlando [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Carlos, Dept Quim, BR-13560970 Sao Carlos, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 26, n. 10, p. 2159-2168, OCT 2015.
Web of Science Citations: 22
Abstract

Simple, fast, and inexpensive electroanalytical procedures were developed for the determination of codeine (COD) solely and paracetamol (PCT) and COD simultaneously in pharmaceutical formulations and human body fluids. The methods involve the combination of square-wave voltammetry (SWV) with a cathodically pretreated boron-doped diamond electrode and a 0.2 mol L-1 acetate buffer (pH 4.0) solution as the supporting electrolyte. Significantly low limits of detection were obtained for COD solely or PCT and COD simultaneously: 1.19 or 18 and 14 nmol L-1, respectively. The proposed SWV method was successfully applied in the simultaneous determination of PCT and COD in four samples of pharmaceutical tablets, with results similar (at 98% confidence level) to those obtained using a reference high-performance liquid chromatography (HPLC) method. Additionally, adequate results were obtained when concentrations of PCT and COD were determined in human urine or serum samples by addition-recovery. Clearly, the proposed method is an excellent option for the determination of COD solely or PCT and COD simultaneously. (AU)

FAPESP's process: 13/16770-0 - SENSORS DEVELOPMENT BASED ON POLYMERIC FILMS AND NANOMATERIALS FOR SEVERAL ANALYTICAL APPLICATIONS
Grantee:Fernando Campanhã Vicentini
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 14/07919-2 - Preparation of electrodes with new carbon-based materials for applications in electroanalytical
Grantee:Patrícia Batista Deroco
Support type: Scholarships in Brazil - Doctorate