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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Structural covariance in schizophrenia and first-episode psychosis: An approach based on graph analysis

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Zugman, Andre [1, 2] ; Assuncao, Idaiane [1] ; Vieira, Gilson [3] ; Gadelha, Ary [1] ; White, Thomas P. [2] ; Oliveira, Pedro Paulo M. [3] ; Noto, Cristiano [1] ; Crossley, Nicolas [2] ; Mcguire, Philip [2] ; Cordeiro, Quirino [4] ; Belangero, Sintia I. O. [5] ; Bressan, Rodrigo A. [1] ; Jackowski, Andrea P. [1] ; Sato, Joao Ricardo [6, 1, 3]
Total Authors: 14
[1] Univ Fed Sao Paulo, Dept Psychiat, LiNC, BR-04039032 Sao Paulo, SP - Brazil
[2] Kings Coll London, Dept Psychosis Studies, Inst Psychiat Psychol & Neurosci, London SE5 8AF - England
[3] Univ Sao Paulo, Sch Med, Inst Radiol, BR-05403900 Sao Paulo, SP - Brazil
[4] Santa Casa Sao Paulo Med Sch, Dept Psychiat, BR-01221020 Sao Paulo, SP - Brazil
[5] Univ Fed Sao Paulo, Dept Morphol & Genet, BR-04023062 Sao Paulo, SP - Brazil
[6] Univ Fed ABC, Ctr Math Computat & Cognit, BR-09210170 Santo Andre, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: JOURNAL OF PSYCHIATRIC RESEARCH; v. 71, p. 89-96, DEC 2015.
Web of Science Citations: 5

Schizophrenia is a neurodevelopmental disorder that produces abnormalities across different brain regions. Measuring structural covariance with MRI is a well-established approach to investigate common changes in distinct systems. We investigated structural covariance in schizophrenia in a large Brazilian sample of individuals with chronic schizophrenia (n = 143), First Episode Psychosis (n = 32), and matched healthy controls (n = 82) using a combination of graph analysis and computational neuroanatomy. Firstly, we proposed the connectivity-closeness and integrity-closeness centrality measures and them compared healthy controls with chronic schizophrenia regarding these metrics. We then conducted a second analysis on the mapped regions comparing the pairwise difference between the three groups. Our results show that compared with controls, both patient groups (in pairwise comparisons) had a reduced integrity-closeness in pars orbitalis and insula, suggesting that the relationship between these areas and other brain regions is increased in schizophrenia. No differences were found between the First Episode Psychosis and Schizophrenia groups. Since in schizophrenia the brain is affected as a whole, this may mirror that these regions may be related to the generalized structural alteration seen in schizophrenia. (c) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 13/10498-6 - Machine learning in neuroimaging: development of methods and clinical applications in psychiatric disorders
Grantee:João Ricardo Sato
Support type: Regular Research Grants
FAPESP's process: 11/50740-5 - Prevention in schizophrenia and bipolar disorder from neuroscience to the community: a multiphase, multimodal and translational platform for research and intervention
Grantee:Rodrigo Affonseca Bressan
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/00506-1 - Time series, wavelets and functional data analysis
Grantee:Pedro Alberto Morettin
Support type: Research Projects - Thematic Grants