The medial amygdaloid nucleus modulates the barore... - BV FAPESP
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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The medial amygdaloid nucleus modulates the baroreflex activity in conscious rats

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Author(s):
Trindade Fortaleza, Eduardo Albino [1] ; Ferreira-Junior, Nilson Carlos [1] ; Lagatta, Davi Campos [1] ; Moraes Resstel, Leonardo Barbosa [1] ; Aguiar Correa, Fernando Morgan [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, BR-14090090 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 193, p. 44-50, DEC 2015.
Web of Science Citations: 4
Abstract

The medial amygdaloid nucleus (MeA) is involved in cardiovascular control. In the present study we report the effect of MeA pharmacological ablations caused by bilateral microinjections of the nonselective synaptic blocker CoCl2 on cardiac baroreflex responses in rats. MeA synaptic inhibition evoked by local bilateral microinjection of 100 nL of CoCl2 (1 mM) did not affect blood pressure or heart rate baseline, suggesting no tonic MeA influence on resting cardiovascular parameters. However, 10 min after CoCl2 microinjection into the MeA of male Wistar rats, the reflex bradycardic response evoked by intravenous infusion of phenylephrine was significantly enhanced when compared with the reflex bradycardic response observed before CoCl2. The treatment did not affect the tachycardic responses to the intravenous infusion of sodium nitroprusside (SNP). Baroreflex activity returned to control values 60 min after CoCl2 microinjections, confirming a reversible blockade. The present results indicate an involvement of the MeA in baroreflex modulation, suggesting that synapses in the MeA have an inhibitory influence on the bradycardic component of the baroreflex in conscious rats. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/18556-2 - Involvement of the glutamatergic system in the paraventricular and supra-optic nucleus on the modulation of the cardiovascular system and the vasopressin and oxytocin release, in rats submitted to osmotic stimuli.
Grantee:Eduardo Albino Trindade Fortaleza
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 11/19494-8 - Involvement of the dorsal hippocampus in the modulation of cardiac baroreflex activity: implication of NMDA, CB1, TRPV1 and muscarinic receptors and of the nitric oxide.
Grantee:Nilson Carlos Ferreira Junior
Support Opportunities: Scholarships in Brazil - Doctorate