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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nutritional Strategies to Modulate Intracellular and Extracellular Buffering Capacity During High-Intensity Exercise

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Lancha Junior, Antonio Herbert [1] ; Painelli, Vitor de Salles [1] ; Saunders, Bryan [1] ; Artioli, Guilherme Giannini [1]
Total Authors: 4
[1] Univ Sao Paulo, Sch Phys Educ & Sport, Lab Appl Nutr & Metab, BR-05508030 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: SPORTS MEDICINE; v. 45, n. 1, p. S71-S81, NOV 2015.
Web of Science Citations: 17

Intramuscular acidosis is a contributing factor to fatigue during high-intensity exercise. Many nutritional strategies aiming to increase intra-and extracellular buffering capacity have been investigated. Among these, supplementation of beta-alanine (similar to 3-6.4 g/day for 4 weeks or longer), the rate-limiting factor to the intramuscular synthesis of carnosine (i.e. an intracellular buffer), has been shown to result in positive effects on exercise performance in which acidosis is a contributing factor to fatigue. Furthermore, sodium bicarbonate, sodium citrate and sodium/calcium lactate supplementation have been employed in an attempt to increase the extracellular buffering capacity. Although all attempts have increased blood bicarbonate concentrations, evidence indicates that sodium bicarbonate (0.3 g/kg body mass) is the most effective in improving high-intensity exercise performance. The evidence supporting the ergogenic effects of sodium citrate and lactate remain weak. These nutritional strategies are not without side effects, as gastrointestinal distress is often associated with the effective doses of sodium bicarbonate, sodium citrate and calcium lactate. Similarly, paresthesia (i.e. tingling sensation of the skin) is currently the only known side effect associated with beta-alanine supplementation, and it is caused by the acute elevation in plasma beta-alanine concentration after a single dose of beta-alanine. Finally, the co-supplementation of beta-alanine and sodium bicarbonate may result in additive ergogenic gains during high-intensity exercise, although studies are required to investigate this combination in a wide range of sports. (AU)

FAPESP's process: 10/11221-0 - Artificial elevation of muscle buffering capacity: effects upon muscle performance and function and underlying mechanisms
Grantee:Antonio Herbert Lancha Junior
Support type: Regular Research Grants
FAPESP's process: 13/04806-0 - Effects of 12 weeks of high-intensity intermittent training on intramuscular carnosine concentrations
Grantee:Vitor de Salles Painelli
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 14/11948-8 - Life without carnosine: development and characterization of a KO rat model for studying the physiological role of carnosine and its implications to physical exercise and muscle metabolism
Grantee:Guilherme Giannini Artioli
Support type: Research Grants - Young Investigators Grants
FAPESP's process: 11/17059-2 - Effects of beta-alanine supplementation combined or not with sodium bicarbonate on intermittent anaerobic performance
Grantee:Guilherme Giannini Artioli
Support type: Scholarships in Brazil - Post-Doctorate