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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Involvement of Kallikrein-Related Peptidases in Normal and Pathologic Processes

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Author(s):
Stefanini, Ana Carolina B. [1, 2] ; da Cunha, Bianca Rodrigues [2, 1] ; Henrique, Tiago [1] ; Tajara, Eloiza H. [2, 1]
Total Authors: 4
Affiliation:
[1] Sch Med Sao Jose do Rio Preto, Dept Mol Biol, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, BR-05508090 Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: DISEASE MARKERS; 2015.
Web of Science Citations: 13
Abstract

Human kallikrein-related peptidases (KLKs) are a subgroup of serine proteases that participate in proteolytic pathways and control protein levels in normal physiology as well as in several pathological conditions. Their complex network of stimulatory and inhibitory interactions may induce inflammatory and immune responses and contribute to the neoplastic phenotype through the regulation of several cellular processes, such as proliferation, survival, migration, and invasion. This family of proteases, which includes one of the most useful cancer biomarkers, kallikrein-related peptidase 3 or PSA, also has a protective effect against cancer promoting apoptosis or counteracting angiogenesis and cell proliferation. Therefore, they represent attractive therapeutic targets and may have important applications in clinical oncology. Despite being intensively studied, many gaps in our knowledge on several molecular aspects of KLK functions still exist. This review aims to summarize recent data on their involvement in different processes related to health and disease, in particular those directly or indirectly linked to the neoplastic process. (AU)

FAPESP's process: 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas
Grantee:Eloiza Helena Tajara da Silva
Support type: Research Projects - Thematic Grants