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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tityus serrulatus venom - A lethal cocktail

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Author(s):
Pucca, Manuela Berto [1] ; Cemi, Felipe Augusto [1] ; Pinheiro Junior, Ernesto Lopes [1] ; Figueiredo Bordon, Karla de Castro [1] ; Amorim, Femanda Gobbi [1] ; Cordeiro, Francielle Almeida [1] ; Longhim, Heloisa Tavoni [1] ; Cremonez, Caroline Marroni [1] ; Oliveira, Guilherme Honda [1] ; Arantes, Eliane Candiani [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Sch Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, BR-14040903 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Toxicon; v. 108, p. 272-284, DEC 15 2015.
Web of Science Citations: 27
Abstract

Tityus serrulatus (Ts) is the main scorpion species of medical importance in Brazil. Ts venom is composed of several compounds such as mucus, inorganic salts, lipids, amines, nucleotides, enzymes, kallikrein inhibitor, natriuretic peptide, proteins with high molecular mass, peptides, free amino acids and neurotoxins. Neurotoxins are considered the most responsible for the envenoming syndrome due to their pharmacological action on ion channels such as voltage-gated sodium (Nay) and potassium OM channels. The major goal of this review is to present important advances in Ts envenoming research, correlating both the crude Ts venom and isolated toxins with alterations observed in all human systems. The most remarkable event lies in the Ts induced massive releasing of neurotransmitters influencing, directly or indirectly, the entire body. Ts venom proved to extremely affect nervous and muscular systems, to modulate the immune system, to induce cardiac disorders, to cause pulmonary edema, to decrease urinary flow and to alter endocrine, exocrine, reproductive, integumentary, skeletal and digestive functions. Therefore, Is venom possesses toxins affecting all anatomic systems, making it a lethal cocktail. However, its low lethality may be due to the low venom mass injected, to the different venom compositions, the body characteristics and health conditions of the victim and the local of Ts sting. Furthermore, we also described the different treatments employed during envenoming cases. In particular, throughout the review, an effort will be made to provide information from an extensive documented studies concerning Is venom in vitro, in animals and in humans (a total of 151 references). (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/07824-1 - Structural and functional characterization of toxins with biotechnological interest present in fraction i from Tityus serrulatus venom
Grantee:Heloisa Tavoni Longhim Peccin
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/12317-3 - Cloning and heterologous expression of hyaluronidase and/or novel toxins obtained from the transcriptome of Tityus serrulatus' venom gland
Grantee:Fernanda Gobbi Amorim
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/12954-6 - Study of the toxins Ts6 e Ts15 from the scorpion Tityus serrulatus as potential therapeutic drugs for the treatment of autoimmune diseases
Grantee:Manuela Berto Pucca
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/13590-8 - Isolation, molecular and functional characterization of a new toxin from Tityus serrulatus scorpion venom
Grantee:Felipe Augusto Cerni
Support type: Scholarships in Brazil - Doctorate