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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

``Photo{''} Chemistry Without Light?

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Baader, Wilhelm J. [1] ; Stevani, Cassius V. [1] ; Bechara, Etelvino J. H. [1]
Total Authors: 3
[1] Univ Sao Paulo, Inst Quim, Dept Quim Fundamental, BR-05508000 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Journal of the Brazilian Chemical Society; v. 26, n. 12, p. 2430-2447, DEC 2015.
Web of Science Citations: 8

In the early seventies, Giuseppe Cilento (Sao Paulo University), Emil White (Johns Hopkins University) and Angelo Lamola (AT\&T Bell Laboratories) postulated that typical photochemical reactions could occur in dark parts of living organisms if coupled to enzymatic sources of electronically excited products. Their paradoxical hypothesis of ``photochemistry without light{''} was chemically anchored on the synthesis and weak chemiluminescence of several 1,2-dioxetanes, unstable cyclic peroxides whose thermal cleavage produces long-lived and reactive triplet carbonyls. Collisional reactions or energy transfer of triplet species to cellular targets could eventually result in ``photo{''} products that potentially trigger normal or pathological responses. These ideas flourished in the labs of various researchers who attempted to explain the presence and biological roles of ``dark{''} secondary metabolites, including plant hormones, pyrimidine dimers, alkaloid lumi-isomers, protein adducts, and mitochondrial permeators, thereby broadening the field of photobiology. (AU)

FAPESP's process: 14/22136-4 - Use of green solvents and their mixtures for optimizing chemical processes
Grantee:Omar Abou El Seoud
Support type: Research Projects - Thematic Grants
FAPESP's process: 08/57721-3 - Redoxome
Grantee:Ohara Augusto
Support type: Research Projects - Thematic Grants
FAPESP's process: 06/56530-4 - Carbonilic and redox stress associated with alpha-aminoketones and endogenous beta-ketoacids: mechanisms and biomarkers.
Grantee:Etelvino José Henriques Bechara
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/16885-1 - Fungal bioluminescence: species survey, mechanistic study & toxicological assays
Grantee:Cassius Vinicius Stevani
Support type: Regular Research Grants