| Full text | |
| Author(s): |
Total Authors: 4
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| Affiliation: | [1] Fed Univ ABC CCNH, UFABC, Ctr Nat Sci & Humanities, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 1
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| Document type: | Journal article |
| Source: | Bioorganic & Medicinal Chemistry; v. 24, n. 2, p. 232-239, JAN 15 2016. |
| Web of Science Citations: | 4 |
| Abstract | |
Nitrone-containing compounds are commonly employed as spin traps of free radical species in chemical and biological studies. Some molecules as alpha-phenyl-N-t-butyl nitrone (PBN) and its derivatives have been tested as potential drugs to treat oxidative stress related diseases, as Alzheimer and stroke for example. In this work we report the design and the synthesis of alpha-aryl-N-aryl nitrones and their cytoprotection profile on human neuroblastoma cells (SH-SY5Y) under induced oxidative stress. All the nine synthesized nitrones showed a significant response at low micromolar concentration. The selected compound 8 (alpha-phenyl-N-phenyl nitrone) increased the reduced glutathione (GSH) levels by 65% and lowered the necrotic cell death from 25.8% to 3.8%. Based on our data, the designed highly conjugated nitrone double-bond skeleton can be considered as a good scaffold for further studies regarding oxidative stress-related diseases. (c) 2015 Elsevier Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 12/01397-9 - Effects of metalloenzyme superoxide dismutase expression in the generation of reactive oxygen species in cultured mammalian cells and in motor neurons |
| Grantee: | Giselle Cerchiaro |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/07717-5 - Nitrones and hydroxylamines with pharmacological properties: synthesis, exploration of antioxidant activity and cellular studies |
| Grantee: | Artur Franz Keppler |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/15534-3 - Síntese de nitronas com potencial farmacológico |
| Grantee: | Giovanna Biazolla |
| Support Opportunities: | Scholarships in Brazil - Scientific Initiation |