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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Parthenogenesis and Human Assisted Reproduction

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Bos-Mikich, Adriana [1] ; Bressan, Fabiana F. [2] ; Ruggeri, Rafael R. [1] ; Watanabe, Yeda [3] ; Meirelles, Flavio V. [2]
Total Authors: 5
[1] Univ Fed Rio Grande do Sul, ICBS, Dept Morphol Sci, BR-90050170 Porto Alegre, RS - Brazil
[2] Univ Sao Paulo, Fac Anim Sci & Food Engn FZEA, Dept Vet Med, BR-13635000 Pirassununga, SP - Brazil
[3] WTA Fertilizacao In Vitro Ltda, BR-14140000 Cravinhos, SP - Brazil
Total Affiliations: 3
Document type: Review article
Web of Science Citations: 7

Parthenogenetic activation of human oocytes obtained from infertility treatments has gained new interest in recent years as an alternative approach to create embryos with no reproductive purpose for research in areas such as assisted reproduction technologies itself, somatic cell, and nuclear transfer experiments and for derivation of clinical grade pluripotent embryonic stem cells for regenerative medicine. Different activating methods have been tested on human and nonhuman oocytes, with varying degrees of success in terms of parthenote generation rates, embryo development stem cell derivation rates. Success in achieving a standardized artificial activation methodology for human oocytes and the subsequent potential therapeutic gain obtained from these embryos depends mainly on the availability of gametes donated from infertility treatments. This review will focus on the creation of parthenotes from clinically unusable oocytes for derivation and establishment of human parthenogenetic stem cell lines and their potential applications in regenerative medicine. (AU)

FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
Grantee:Dimas Tadeu Covas
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC