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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Response to immunization in children born to renal transplant recipients using immunosuppressive drugs during gestation

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Saraiva Dinelli, Maria Isabel [1] ; Ono, Erika [1] ; Viana, Patricia Oliveira [1] ; Spina, Fernanda Garcia [1] ; Weckx, Lily Yin [1] ; Nunes dos Santos, Amelia Miyashiro [1] ; de Moraes-Pinto, Maria Isabel [1]
Total Authors: 7
[1] Univ Fed Sao Paulo, Dept Pediat, Div Pediat Infect Dis, Rua Pedro Toledo, 781-9 Andar Sao Paulo, BR-04039032 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Vaccine; v. 34, n. 4, p. 404-407, JAN 20 2016.
Web of Science Citations: 3

The use of immunosuppressive drugs can impair vaccination responses. When used during pregnancy, they may interfere with the development of the fetus's immune system. However, little is known regarding their influence on infant's response to vaccinations. Twenty-seven children born to renal transplant mothers (Tx) taking immunosuppressive drugs and 31 healthy children had the humoral immune response and reactogenicity to tetanus, Haemophilus influenzae type b (Hib) and 7 pneumococcal serotypes evaluated. The evolution of BCG vaccine scar was also registered. Antibodies were measured by ELISA. Lymphocyte immunophenotyping was performed on cord blood and at 7-8 months of age. Among Tx neonates, 82.4% had low B lymphocyte numbers at birth, and 29.4% had also low numbers of other lymphocyte subpopulations. Nevertheless, all children developed protective antibodies with similar antibody concentrations to the control group. Vaccine reactogenicity was similar in both groups and BCG healing was uneventful. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 08/11670-9 - Children born to renal transplant recipients: immunologic assessment, placental antibody transfer and response to vaccination
Grantee:Maria Isabel de Moraes Pinto
Support Opportunities: Regular Research Grants