Nanostructures for protein drug delivery

Author(s)

Pachioni-Vasconcelos, Juliana de Almeida ^[1] ; Lopes, Andre Moreni ^[1] ; Apolinario, Alexsandra Conceicao ^[1] ; Valenzuela-Oses, Johanna Karina ^[1] ; Ribeiro Costa, Juliana Souza ^[2] ; Nascimento, Laura de Oliveira ^{[2, 3]} ; Pessoa, Jr., Adalberto ^[1] ; Souza Barbosa, Leandro Ramos ^[4] ; Rangel-Yagui, Carlota de Oliveira ^[1]

Affiliation

^[1] Univ Sao Paulo, Sch Pharmaceut Sci, Dept Biochem & Pharmaceut Technol, BR-05508 Sao Paulo - Brazil

^[2] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Campinas, SP - Brazil

^[3] Univ Estadual Campinas, Fac Pharmaceut Sci, Campinas, SP - Brazil

^[4] Univ Sao Paulo, Inst Phys, Dept Gen Phys, BR-05508 Sao Paulo - Brazil

• Document type: Review article
• Source: BIOMATERIALS SCIENCE; v. 4, n. 2, p. 205-218, 2016.
• Web of Science Citations: 25

Abstract

Use of nanoscale devices as carriers for drugs and imaging agents has been extensively investigated and successful examples can already be found in therapy. In parallel, recombinant DNA technology together with molecular biology has opened up numerous possibilities for the large-scale production of many proteins of pharmaceutical interest, reflecting in the exponentially growing number of drugs of biotechnological origin. When we consider protein drugs, however, there are specific criteria to take into account to select adequate nanostructured systems as drug carriers. In this review, we highlight the main features, advantages, drawbacks and recent developments of nanostructures for protein encapsulation, such as nanoemulsions, liposomes, polymersomes, single-protein nanocapsules and hydrogel nanoparticles. We also discuss the importance of nanoparticle stabilization, as well as future opportunities and challenges in nanostructures for protein drug delivery. (AU)

• FAPESP's process: 14/01983-0 - Synthesis and nanotechnological development of miltefosine homocholinic analogs
• Grantee: Carlota de Oliveira Rangel Yagui
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/16588-7 - Nanostructured biopolymers to deliver antimicrobial peptides with leishmanicidal activity
• Grantee: Laura de Oliveira Nascimento
• Support Opportunities: Regular Research Grants
• FAPESP's process: 13/08617-7 - Production of extracellular L-asparaginase: from bioprospecting to the engineering of an antileukemic biopharmaceutical
• Grantee: Adalberto Pessoa Junior
• Support Opportunities: Research Projects - Thematic Grants
• FAPESP's process: 14/10456-4 - Development and characterization of poly(ethylene glycol) methyl ether-Block-Poly (D,L-Lactide) (PEG-PLA) Polymersomes for the release of recombinant L-asparaginase
• Grantee: Alexsandra Conceição Apolinário
• Support Opportunities: Scholarships in Brazil - Doctorate