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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

GABA mechanisms of the nucleus of the solitary tract regulates the cardiovascular and sympathetic effects of moxonidine

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Author(s):
Alves, Thales B. [1] ; Totola, Leonardo T. [1] ; Takakura, Ana C. [2] ; Colombari, Eduardo [3] ; Moreira, Thiago S. [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Physiol & Biophys, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Inst Biomed Sci, Dept Pharmacol, Sao Paulo, SP - Brazil
[3] Sao Paulo State Univ, Sch Dent, Dept Physiol & Pathol, Araraquara, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL; v. 194, p. 1-7, JAN 2016.
Web of Science Citations: 2
Abstract

The antihypertensive drugs moxonidine and clonidine are alpha(2)-adrenoceptor and imidazoline (I-1) agonists. Previous results from our laboratory have shown that moxonidine can act in the commissural nucleus of the solitary tract (commNTS). In addition, some studies have shown that GABA or glutamate receptor blockade in the RVLM blunted the hypotension produced by these antihypertensive agents in spontaneously hypertensive rats. Therefore, in the present study we verify whether the cardiovascular and sympathetic effects produced by moxonidine in the commNTS are dependent on GABAergic or glutamatergic mechanisms. Mean arterial pressure (MAP) and splanchnic sympathetic nerve activity (sSNA) were recorded in urethane-anesthetized, and artificially-ventilated male Wistar rats (250-350 g). Injection of the GABAA antagonist bicuculline (25 pmol/50 nL) into the commNTS reduced the hypotension as well as the sympathoinhibition elicited by moxonidine. Prior injection of the glutamate receptor antagonist kynurenic acid (2.5 nmo1/50 nL) into the commNTS was not effective in reducing the hypotension and sympathoinhibition elicited by moxonidine. Therefore, we conclude that the hypotensive and sympathoinhibitory effects elicited by microinjection of moxonidine into the commNTS are dependent on GABA receptors, but not ionotropic glutamate receptors. (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 11/11934-9 - Evaluation of cardiovascular and sympathetic responses promoted by moxonidine injection in the commissural nucleus of the solitary tract in rats
Grantee:Thales Biffe Alves
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 13/10573-8 - Ventral surface chemoreceptor neuronal mechanisms
Grantee:Thiago dos Santos Moreira
Support type: Regular Research Grants
FAPESP's process: 09/54888-7 - Neural mechanisms involved on chemoreception
Grantee:Eduardo Colombari
Support type: Research Projects - Thematic Grants
FAPESP's process: 14/22406-1 - Respiratory anatomofunctional changes observed in an experimental model of Parkinson Disease
Grantee:Ana Carolina Thomaz Takakura
Support type: Regular Research Grants