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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A new homoleptic coordination compound of ruthenium and norfloxacin and its interaction with human serum albumin

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Author(s):
Claro Reis, Felipe Costa [1] ; Viana Coelho, Joana Stefani [1] ; Pazin, Wallance Moreira [2] ; Nikolaou, Sofia [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Quim, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Fac Filosofia Ciencias & Letras Ribeirao Preto, Dept Fis, Av Bandeirantes 3900, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Inorganic Chemistry Communications; v. 63, p. 96-100, JAN 2016.
Web of Science Citations: 4
Abstract

This work presents a new coordination compound of ruthenium and the norfloxacin antibiotics, as well as its interaction with human serum albumin (HSA). The ESI HRMS spectrum of {[}Ru(nor)(3)] (nor = norfloxacinate, C16H17FN3O3-) displayed the protonated molecular ion at m/z 1057.3, while the HRMS/MS spectra displayed peaks at m/z 958.4 and 639.3 assigned to the gaseous phase norfloxacin adducts (Hnor)(3).H+ and (Hnor)(2).H+. Coordination to Ru(III) remarkably enhances the water solubility of norfloxacin. The complex absorption spectrum in aqueous medium is dominated by the norfloxacin transitions in the UV region but also displays a broad shoulder around 370 nm, which possibly overlaps with ligand-field transitions. Stern-Volmer analysis of human serum albumin (HSA) fluorescence quenching by {[}Ru(nor)(3)] showed that both dynamic and static mechanisms contribute to the quenching. Lifetime measurements demonstrated that the predominance of one pathway over the other depends on temperature variations. Finally, the analysis of thermodynamic parameters leads to the conclusions that the interaction of the novel complex with HSA is spontaneous and that this interaction occurs through the formation of hydrogen bonds and van der Weals forces (Delta H = -259.2 kJ/mol and Delta S = -779.9 kJ/mol.K). (C) 2015 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/23245-6 - Nitric oxide releasers based on ruthenium carboxylates and their interaction with some relevant biomolecules
Grantee:Sofia Nikolaou
Support Opportunities: Regular Research Grants