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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aerobic Exercise and Pharmacological Therapies for Skeletal Myopathy in Heart Failure: Similarities and Differences

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Bacurau, Aline V. [1] ; Cunha, Telma F. [1] ; Souza, Rodrigo W. [1] ; Voltarelli, Vanessa A. [1] ; Gabriel-Costa, Daniele [1] ; Brum, Patricia C. [1]
Total Authors: 6
[1] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Review article
Web of Science Citations: 8

Skeletal myopathy has been identified as a major comorbidity of heart failure (HF) affecting up to 20% of ambulatory patients leading to shortness of breath, early fatigue, and exercise intolerance. Neurohumoral blockade, through the inhibition of renin angiotensin aldosterone system (RAS) and beta-adrenergic receptor blockade (beta-blockers), is a mandatory pharmacological therapy of HF since it reduces symptoms, mortality, and sudden death. However, the effect of these drugs on skeletal myopathy needs to be clarified, since exercise intolerance remains in HF patients optimized with beta-blockers and inhibitors of RAS. Aerobic exercise training (AET) is efficient in counteracting skeletal myopathy and in improving functional capacity and quality of life. Indeed, AET has beneficial effects on failing heart itself despite being of less magnitude compared with neurohumoral blockade. In this way, AET should be implemented in the care standards, together with pharmacological therapies. Since both neurohumoral inhibition and AET have a direct and/or indirect impact on skeletal muscle, this review aims to provide an overview of the isolated effects of these therapeutic approaches in counteracting skeletal myopathy in HF. The similarities and dissimilarities of neurohumoral inhibition and AET therapies are also discussed to identify potential advantageous effects of these combined therapies for treating HF. (AU)

FAPESP's process: 14/25957-9 - Influence of aerobic fitness in redox homeostasis: identification and biological implications of cysteine residues oxidation in cardiac and skeletal muscle proteins
Grantee:Rodrigo Wagner Alves de Souza
Support Opportunities: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 10/50048-1 - Cellular and functional bases of exercise in cardiovascular diseases
Grantee:Carlos Eduardo Negrão
Support Opportunities: Research Projects - Thematic Grants