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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Rate of tuberculosis infection in children and adolescents with household contact with adults with active pulmonary tuberculosis as assessed by tuberculin skin test and interferon-gamma release assays

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Ferrarini, M. A. G. [1] ; Spina, F. G. [1] ; Weckx, L. Y. [1] ; Lederman, H. M. [2] ; De Moraes-Pinto, M. I. [1]
Total Authors: 5
[1] Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Diagnost Imaging, Sao Paulo, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: EPIDEMIOLOGY AND INFECTION; v. 144, n. 4, p. 712-723, MAR 2016.
Web of Science Citations: 3

Tuberculosis (TB) infection was evaluated in Brazilian immunocompetent children and adolescents exposed and unexposed (control group) to adults with active pulmonary TB. Both groups were analysed by clinical and radiological assessment, TST, QFT-IT and T-SPOT. TB. The three tests were repeated after 8 weeks in the TB-exposed group if results were initially negative. Individuals with latent tuberculosis infection (LTBI) were treated and tests were repeated after treatment. Fifty-nine TB-exposed and 42 controls were evaluated. Rate of infection was 69.5% and 9.5% for the exposed and control groups, respectively. The exposed group infection rate was 61% assessed by TST, 57.6% by T-SPOT. TB, and 59.3%, by QFT-IT. No active TB was diagnosed. Agreement between the three tests was 83.1% and 92.8% in the exposed and control groups, respectively. In the exposed group, T-SPOT. TB added four TB diagnoses {[}16%, 95% confidence interval (CI) 1.6-30.4] and QFT-IT added three TB diagnoses (12%, 95% CI 0-24.7) in 25 individuals with negative tuberculin skin test (TST). Risk factors associated to TB infection were contact with an adult with active TB {[}0-60 days: odds ratio (OR) 6.9; >60 days: OR 27.0] and sleeping in the same room as an adult with active TB (OR 5.2). In Brazilian immunocompetent children and adolescents, TST had a similar performance to interferon-gamma release assays and detected a high rate of LTBI. (AU)

FAPESP's process: 09/07603-7 - Risk for tuberculosis among children living with adults with sputum positive pulmonary tuberculosis as assessed by tuberculin skin test, QuantiFERON and ELISpot
Grantee:Lily Yin Weckx
Support type: Regular Research Grants