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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Moderate and intense exercise lifestyles attenuate the effects of aging on telomere length and the survival and composition of T cell subpopulations

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Author(s):
Rodrigues Silva, Leia Cristina [1] ; de Araujo, Adriana Ladeira [1] ; Fernandes, Juliana Ruiz [1] ; Toledo Matias, Manuella de Sousa [2] ; Silva, Paulo Roberto [3] ; Duarte, Alberto J. S. [1] ; Garcez Leme, Luiz Eugenio [2] ; Benard, Gil [4, 1, 5]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Sch Med, Clin Hosp, Lab Dermatol & Immunodeficiencies, Dermatol Div, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Sch Med, Dept Orthoped & Traumatol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Sch Med, Dept Orthoped & Traumatol, Lab Movement Studies, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Trop Med, Med Mycol Lab, Sao Paulo - Brazil
[5] R Dr Eneas Carvalho Aguiar, 470 Cerqueira Cesar, BR-05403903 Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: AGE; v. 38, n. 1 FEB 2016.
Web of Science Citations: 22
Abstract

Studies indicate that exercise might delay human biological aging, but the effects of long-term exercise on T cell function are not well known. We tested the hypothesis that moderate or intense exercise lifestyle may attenuate the effects of aging on the telomere length and the survival and composition of T cell subpopulations. Elderly (65-85 years) with intense training lifestyle (IT, n = 15), moderate training lifestyle (MT, n = 16), and who never trained (NT, n = 15) were studied. Although the three groups presented the ageassociated contraction of the TCD4(+)/TCD8(+) naive compartments and expansion of the memory compartments, both training modalities were associated with lower proportion of terminally differentiated (CD45RA(+) CCR7(neg)) TCD4 (+) and TCD8(+) cells, although among the latter cells, the reduction reached statistical significance only with IT. MT was associated with higher proportion of central memory TCD4(+) cells, while ITwas associated with higher proportion of effector memory TCD8(+) cells. However, both training lifestyles were unable to modify the proportion of senescent (CD28(neg)) TCD8(+) cells. Telomeres were longer in T cells in both training groups; with IT, telomere length increased mainly in TCD8(+) cells, whereas with MT, a modest increase in telomere length was observed in both TCD8(+) and TCD4(+) cells. Reduced commitment to apoptosis of resting T cells, as assessed by caspase-3 and Bcl-2 expression, was seen predominantly with IT. Measurement of pro-inflammatory cytokines in serum and peripheral blood mononuclear cell (PBMC)' s supernatants did not show chronic low-grade inflammation in any of the groups. In conclusion, MT and IT lifestyles attenuated some of the effects of aging on the immune system. (AU)

FAPESP's process: 11/18268-4 - Impact of regular moderate physical activity in delaying immunosenescence in elderly people
Grantee:Léia Cristina Rodrigues da Silva
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/08817-0 - Effect of regular high performance aerobic exercises in immune response and in telomere shortening in T lymphocytes from elderly people
Grantee:Gil Benard
Support Opportunities: Regular Research Grants