| Full text | |
| Author(s): Show less - |
Fonseca, Felipe P.
[1, 2]
;
Bingle, Lynne
[2]
;
Santos-Silva, Alan R.
[1]
;
Lopes, Marcio A.
[1]
;
de Almeida, Oslei P.
[1]
;
de Andrade, Bruno A. B.
[3]
;
Mariano, Fernanda V.
[1]
;
Kowalski, Luiz P.
[4]
;
Rangel, Ana L. C. A.
[5]
;
Martins, Manoela D.
[6, 7]
;
Meurer, Luise
[6, 7]
;
Speight, Paul M.
[2]
;
Vargas, Pablo A.
[8, 1]
Total Authors: 13
|
| Affiliation: | [1] Univ Estadual Campinas, Piracicaba Dent Sch & Fac Med, Piracicaba - Brazil
[2] Univ Sheffield, Sch Clin Dent, Dept Oral & Maxillofacial Pathol, Sheffield, S Yorkshire - England
[3] Univ Fed Rio de Janeiro, Sch Dent, Rio De Janeiro - Brazil
[4] AC Camargo Canc Ctr, Dept Otorhinolaryngol Head & Neck Surg, Sao Paulo - Brazil
[5] State Univ Western Parana, Sch Dent, Cascavel - Brazil
[6] Univ Fed Rio Grande do Sul, Sch Med, BR-90046900 Porto Alegre, RS - Brazil
[7] Univ Fed Rio Grande do Sul, Sch Dent, BR-90046900 Porto Alegre, RS - Brazil
[8] Univ Pretoria, Fac Hlth Sci, Sch Dent, Dept Oral Pathol & Oral Biol, ZA-0002 Pretoria - South Africa
Total Affiliations: 8
|
| Document type: | Journal article |
| Source: | JOURNAL OF ORAL PATHOLOGY & MEDICINE; v. 45, n. 2, p. 119-126, FEB 2016. |
| Web of Science Citations: | 4 |
| Abstract | |
BackgroundSalivary gland tumors (SGT) account for 3-10% of all head and neck neoplasms, and little is known about their angiogenic properties. Despite semaphorins and neuropilins have been demonstrated to be prognostic determinants in many human cancers, they remain to be investigated in SGT. Therefore, the objective of this study was to analyze the clinical significance of the expression of class 3 semaphorins A (Sema3A) and B (Sema3B) and neuropilins-1 (Np-1) and neuropilins-2 (Np-2), in SGT. MethodsTwo hundred and forty-eight SGT were organized in tissue microarray paraffin blocks and expression of CD34, Sema3A, Sema3B, Np-1, and Np-2 was determined through immunohistochemistry. The immunoreactions were quantified using digital algorithms and the results correlated with clinicopathological parameters. ResultsMalignant tumors had an increased vascular density than their benign counterparts and their increased vascular area significantly correlated with recurrences (P<0.05). Patients older than 40years and the presence of recurrences determined an inferior survival rate (P=0.0057 and P=0.0303, respectively). In normal salivary glands, Np-1 and Np-2 expression was restricted to ductal cells, whereas Sema3A and Sema3B were positive in the serous acinar compartment. Tumors were positive for all markers and the co-expression of Np-1/Np-2 significantly correlated with the presence of paresthesia and advanced stages of the tumors (P=0.01 and P=0.04, respectively). ConclusionSema3A, Sema3B, Np-1, and Np-2 may be involved in the pathogenesis of SGT, but their expression did not present a statistically significant prognostic potential in this study. (AU) | |
| FAPESP's process: | 12/07519-9 - SEMAPHORINS AND NEUROPILINS IN SALIVARY GLAND TUMORS |
| Grantee: | Felipe Paiva Fonseca |
| Support Opportunities: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 09/53839-2 - Creation of a Digital Pathology Laboratory using a histological slidescanner |
| Grantee: | Oslei Paes de Almeida |
| Support Opportunities: | Multi-user Equipment Program |
| FAPESP's process: | 12/10781-7 - Analysis of the expression of cytokeratins, angiogenic and proliferative patterns, and DNA content of salivary gland tumors |
| Grantee: | Pablo Agustin Vargas |
| Support Opportunities: | Regular Research Grants |