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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of genetic ancestry on the risk of obstructive sleep apnoea syndrome

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Author(s):
Guindalini, C. [1] ; Colugnati, F. A. B. [2] ; Pellegrino, R. [1] ; Santos-Silva, R. [1] ; Bittencourt, L. R. A. [1] ; Tufik, S. [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psychobiol, Escola Paulista Med, BR-04024002 Sao Paulo - Brazil
[2] Inst Pesquisas Tecnol & Inovacao, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: European Respiratory Journal; v. 36, n. 4, p. 834-841, OCT 2010.
Web of Science Citations: 15
Abstract

The aim of the present study was to evaluate the influence of ethnicity on the risk of developing obstructive sleep apnoea syndrome (OSAS) using genomic analysis methods to estimate ancestry. DNA samples were obtained from 1,010 individuals participating in the Sao Paulo Epidemiologic Sleep Study, who underwent full-night polysomnography. A total of 31 genetic ancestry-informative markers were selected in order to estimate individual admixture proportions. Of patients with a diagnosis of OSAS, a higher number self-reporting Caucasian ethnicity (65.3%), as well as an increased percentage of European ancestry (78.2 +/- 16.7%) and lower percentage of West African ancestry (16.1 +/- 15.3%), than among individuals without OSAS (53.6, 73.5 +/- 18.1 and 20.1 +/- 16.8%, respectively) (p < 0.001) was observed. Moreover, after correcting for sex, age, body mass index and socioeconomic status, logistic regression demonstrated that European ancestry was significantly associated with an increased risk of manifesting OSAS (OR 2.80, 95% CI 1.11-7.09). Conversely, West African ancestry was associated with a reduced risk of the OSAS phenotype (OR 0.26, 95% CI 0.09-0.72). This is the first study to incorporate genomic analysis methods to measure the influence of ethnicity on the risk of OSAS. Since genetically determined ancestry may not capture unmeasured cultural and lifestyle differences, the contribution of environmental factors to the current findings should not be disregarded. (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC