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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of Anti-Infective Mechanical Therapy on Clinical Parameters and Cytokine Levels in Human Peri-Implant Diseases

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Duarte, Poliana Mendes [1] ; de Mendonca, Adriana Cutrim [1] ; Braz Maximo, Maria Beatriz [1] ; Santos, Vanessa Renata [1] ; Bastos, Marta Ferreira [1] ; Nociti, Jr., Francisco Humberto [2]
Total Authors: 6
[1] Univ Guarulhos, Dent Res Div, Dept Periodont, Guarulhos, SP - Brazil
[2] Univ Estadual Campinas, Sch Dent Piracicaba, Dept Prosthodont Periodont, Div Periodont, Piracicaba, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of Periodontology; v. 80, n. 2, p. 234-243, FEB 2009.
Web of Science Citations: 57

Background: The objectives of this study were to clinically and immunologically assess the effects of mechanical anti-infective therapies for mucositis and peri-implantitis and to compare the levels of cytokines in untreated and treated peri-implant diseased sites to healthy ones. Methods: Titanium dental implants were assigned to one of the following groups: healthy (n = 10) = control; mucositis (n = 10) = mechanical debridement using abrasive sodium carbonate air-powder and resin curets; and peri-implantitis (n = 20) = open surgical debridement using abrasive sodium carbonate air-powder and resin curets. Visible plaque accumulation, marginal bleeding, bleeding on probing, suppuration, and probing depth were assessed at baseline for all groups and at 3 months after therapies for diseased groups. At these times, the total amounts of interleukin (IL)-4, -10, and -12, tumor necrosis factor-alpha (TNF-alpha), receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG) in the peri-implant crevicular fluid (PICF) were measured by enzyme-linked immunosorbent assay. Results: At 3 months, the anti-infective treatments resulted in a significant improvement in all clinical parameters for mucositis and peri-implantitis (P<0.05). Moreover, the total amounts of TNF-a in PICF were significantly higher in untreated diseased implants compared to healthy ones, and the OPG/RANKL ratio was higher for healthy implants than for untreated peri-implantitis (P<0.05). TNF-a levels were significantly reduced for both diseased groups (P0.05), achieving the same level as the healthy group at 3 months after therapies (P>0.05). Conclusion: The proposed anti-infective therapies may locally modulate the levels of TNF-a and the OPG/RANKL ratio and improve clinical parameters around peri-implant tissues. J Periodontol 2009; 80:234-243. (AU)

FAPESP's process: 05/02561-3 - Microbiological and pro-inflammatory and anti-inflammatory cytokine expression profiles in different forms of human peri-implantitis
Grantee:Poliana Mendes Duarte
Support type: Regular Research Grants
FAPESP's process: 06/04604-4 - RANKL and osteoprotegerin expression in gingival fluid and tissue in different peri-implantitis severity before and after anti-infection therapy: a study in human beings
Grantee:Vanessa Renata Santos da Silva
Support type: Scholarships in Brazil - Master