| Full text | |
| Author(s): Show less - |
Pereira, Bruna L. B.
[1]
;
Arruda, Fernanda C. O.
[1]
;
Reis, Patricia P.
[2]
;
Felix, Tainara F.
[2]
;
Santos, Priscila P.
[1]
;
Rafacho, Bruna P.
[1]
;
Goncalves, Andrea F.
[1]
;
Claro, Renan T.
[1]
;
Azevedo, Paula S.
[1]
;
Polegato, Bertha F.
[1]
;
Okoshi, Katashi
[1]
;
Fernandes, Ana A. H.
[3]
;
Paiva, Sergio A. R.
[1]
;
Zornoff, Leonardo A. M.
[1]
;
Minicucci, Marcos F.
[1]
Total Authors: 15
|
| Affiliation: | [1] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Internal Med, BR-18618970 Botucatu, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Botucatu Med Sch, Dept Surg & Orthoped, BR-18618970 Botucatu, SP - Brazil
[3] Univ Estadual Paulista, UNESP, Inst Biosci, Dept Chem & Biochem, BR-18618970 Botucatu, SP - Brazil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | NUTRIENTS; v. 7, n. 11, p. 9640-9649, NOV 2015. |
| Web of Science Citations: | 6 |
| Abstract | |
The aim of this study was to evaluate the effects of tomato supplementation on the normal rat heart and the role of oxidative stress in this scenario. Male Wistar rats were assigned to two groups: a control group (C; n = 16), in which animals received a control diet + 0.5 mL of corn oil/kg body weight/day, and a tomato group (T; n = 16), in which animals received a control diet supplemented with tomato +0.5 mL of corn oil/kg body weight/day. After three months, morphological, functional, and biochemical analyses were performed. Animals supplemented with tomato had a smaller left atrium diameter and myocyte cross-sectional area (CSA) compared to the control group (C group: 474 (415-539); T group: 273 (258-297) mu m(2); p = 0.004). Diastolic function was improved in rats supplemented with tomato. In addition, lipid hydroperoxide was lower (C group: 267 +/- 46.7; T group: 219 +/- 23.0 nmol/g; p = 0.039) in the myocardium of rats supplemented with tomato. Tomato intake was also associated with up-regulation of miR-107 and miR-486 and down-regulation of miR-350 and miR-872. In conclusion, tomato supplementation induces changes in miRNA expression and reduces oxidative stress. In addition, these alterations may be responsible for CSA reduction and diastolic function improvement. (AU) | |
| FAPESP's process: | 12/16471-0 - Influence of tomato and lycopene supplementation on the cardiac remodeling after acute myocardial infarction |
| Grantee: | Bruna Letícia Buzati Pereira |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 12/17414-0 - Influence of tomato and lycopene supplementation on the cardiac remodeling after acute myocardial infarction |
| Grantee: | Marcos Ferreira Minicucci |
| Support Opportunities: | Regular Research Grants |