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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Sleep, Hansen's disease and the immune system - A not so harmonic triad

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Author(s):
Albuquerque, Rachel Gimenes [1] ; Okazaki, Keity Mey [1] ; Hirotsu, Camila [1] ; Tomimori, Jane [2] ; Tufik, Sergio [1] ; Andersen, Monica Levy [1]
Total Authors: 6
Affiliation:
[1] Univ Fed Sao Paulo, Dept Psychobiol, BR-04024002 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Dermatol, BR-04038001 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Medical Hypotheses; v. 84, n. 5, p. 456-459, MAY 2015.
Web of Science Citations: 0
Abstract

Hansen's disease is one of the oldest skin diseases in the world characterized by a spectrum of clinical manifestations that are associated with stigmatization and poor quality of life. It is also considered a model disease for investigating the human immune system because of its association with immune reactions, which are thought to be a reflection of the host's immunological response, promoting intense cellular activity or humoral secretion. This relationship between the cellular and microbial components of skin and their regulation by local immune responses may be modulated by a currently neglected behavior: sleep. Recent studies have demonstrated that sleep deprivation may aggravate the progression of chronic dermatological diseases, which in turn can lead to a non-restorative sleep pattern. Indeed, sleep is essential for immune and skin integrity. Thus, we propose here a hypothesis linking Hansen's disease, sleep and immunity in a bidirectional relationship. Hansen's disease patients may demonstrate a worse sleep quality than the general population through the modulation of immunological environment; and sleep restriction, a hallmark of modern society, being a possible predictor of the disease progression. (C) 2015 Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 14/00923-4 - Impact of sleep restriction and deprivation on rats skin ageing
Grantee:Rachel Gimenes Rodrigues Albuquerque
Support type: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/21794-2 - The role of sleep and sildenafil in the progression of chronic kidney disease: a new therapeutic approach
Grantee:Monica Levy Andersen
Support type: Regular Research Grants
FAPESP's process: 14/15259-2 - Epidemiology of sleep in the city of São Paulo: follow-up of volunteers from the population-based study EPISONO
Grantee:Camila Hirotsu
Support type: Scholarships in Brazil - Post-Doctorate