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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Involvement of miRNAs and Cell-Secreted Vesicles in Mammalian Ovarian Antral Follicle Development

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Author(s):
da Silveira, Juliano C. [1] ; de Andrade, Gabriella M. [1] ; Nogueira, Marcelo F. G. [2] ; Meirelles, Flavio V. [1] ; Perecin, Felipe [1]
Total Authors: 5
Affiliation:
[1] Univ Sao Paulo, Fac Anim Sci & Food Engn, Dept Vet Med, BR-13635900 Pirassununga, SP - Brazil
[2] Univ Sao Paulo State, Fac Sci & Letters, Dept Biol Sci, Assis, SP - Brazil
Total Affiliations: 2
Document type: Review article
Source: REPRODUCTIVE SCIENCES; v. 22, n. 12, p. 1474-1483, DEC 2015.
Web of Science Citations: 13
Abstract

Ovarian follicular development is a controlled series of events culminating with an ovulatory or atretic follicle. MicroRNAs (miRNAs) are small noncoding RNAs involved in translational regulation of genes in different developmental processes. Deletion of Dicer in mice ovaries demonstrated the importance of miRNAs in reproduction, which led to infertility. The miRNAs were thought to act only within host cells; however, these molecules are also present in cell-secreted vesicles. These vesicles are present in body fluids such as milk, serum, and ovarian follicular fluid. Vesicles are secreted in extracellular fluids and travel from donor to target cells, mediating transfer of bioactive material. Herein we discuss the role of hormonal-regulated miRNAs within different ovarian follicular cells as well as cell-secreted vesicles participation in mammalian ovarian follicular fluid. Furthermore, we discuss the possibility of miRNAs transference mediated by cell-secreted vesicles present in ovarian follicular fluid, increasing the versatility of miRNA functions during antral follicle development. (AU)

FAPESP's process: 13/10473-3 - Role of cell-secreted vesicles in ovarian follicular fluid during oocyte maturation and their involvement in controlling epigenetic changes
Grantee:Juliano Coelho da Silveira
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 12/50533-2 - GIFT: genomic improvement of fertilization traits in Danish and Brazilian cattle
Grantee:Marcelo Fábio Gouveia Nogueira
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/08135-2 - CTC - Center for Cell-Based Therapy
Grantee:Dimas Tadeu Covas
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC