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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epidemiology and molecular mechanisms of antifungal resistance in Candida and Aspergillus

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Author(s):
Goncalves, Sarah Santos [1] ; Remondi Souza, Ana Carolina [1] ; Chowdhary, Anuradha [2] ; Meis, Jacques F. [3, 4] ; Colombo, Arnaldo Lopes [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Lab Especial Micol, Disciplina Infectol, Escola Paulista Med, BR-04039032 Sao Paulo, SP - Brazil
[2] Univ Delhi, Vallabhbhai Patel Chest Inst, Dept Med Mycol, Delhi 110007 - India
[3] Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen - Netherlands
[4] Radboud Univ Nijmegen, Dept Med Microbiol, NL-6525 ED Nijmegen - Netherlands
Total Affiliations: 4
Document type: Review article
Source: MYCOSES; v. 59, n. 4, p. 198-219, APR 2016.
Web of Science Citations: 51
Abstract

The significant increase in the use of antifungal agents, both for the treatment of candidiasis and invasive aspergillosis and as azole fungicides in agricultural crop protection has resulted in the emergence of resistant clinical isolates, particularly to triazoles and echinocandins. Notably, among isolates that were primarily sensitive to fluconazole such as Candida parapsilosis and Candida tropicalis have witnessed an emerging resistance development. Also for echinocandins, the occurrence of Candida isolates with lower susceptibility to these drugs has been reported, which is possibly due to its broad clinical use. Triazole resistance among Aspergillus fumigatus and other Aspergillus species is commonly found in European and Asian countries. Specific mutations are associated with azole resistance in A. fumigatus and these mutations are now reported globally from six continents. Therefore, we highlight the need to conduct antifungal resistance surveillance studies using clinical isolates of Candida and Aspergillus in different geographical regions and monitoring of the infection rates in distinct population groups for early detection of resistance to these drugs and implementation of efficient policies for infection control and treatment. (AU)

FAPESP's process: 12/04767-1 - Candida parapsilosis complex: epidemiological peculiarities, virulence and mechanisms of antifungal resistance
Grantee:Arnaldo Lopes Colombo
Support Opportunities: Regular Research Grants
FAPESP's process: 12/04769-4 - Candida parapsilosis complex: epidemiological peculiarities, virulence and mechanisms of antifungal resistance
Grantee:Ana Carolina Remondi Souza
Support Opportunities: Scholarships in Brazil - Doctorate