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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Thyroid-Specific Genes Expression Uncovered Age-Related Differences in Pediatric Thyroid Carcinomas

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Author(s):
Cunha Vieira Cordioli, Maria Isabel [1, 2] ; Moraes, Lais [1, 2] ; de Seixas Alves, Maria Teresa [3] ; Delcelo, Rosana [4] ; Monte, Osmar [5] ; Longui, Carlos Alberto [5] ; Cury, Adriano Namo [6] ; Cerutti, Janete Maria [1, 2]
Total Authors: 8
Affiliation:
[1] Univ Fed Sao Paulo, Dept Morphol & Genet, Div Genet, Genet Bases Thyroid Tumors Lab, Pedro de Toledo 669, 11 Andar, BR-04039032 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Div Endocrinol, Pedro de Toledo 669, 11 Andar, BR-04039032 Sao Paulo, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Pathol, Pediat Sect, Rua Botucatu 740, BR-04023900 Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Dept Pathol, Thyroid Sect, Rua Botucatu 740, BR-04023900 Sao Paulo, SP - Brazil
[5] Irmandade Santa Casa Miserordia Sao Paulo, Mol Med Lab, Rua Dr Cesario Mota Jr 112, BR-01221020 Sao Paulo, SP - Brazil
[6] Irmandade Santa Casa Miserordia Sao Paulo, Div Endocrinol, Rua Dr Cesario Mota Jr 112, BR-01221020 Sao Paulo, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: INTERNATIONAL JOURNAL OF ENDOCRINOLOGY; 2016.
Web of Science Citations: 8
Abstract

Despite a more advanced stage of disease at presentation, a better response to radioiodine (RAI) therapy and a reduced overall mortality have been reported in pediatric differentiated thyroid cancer (DTC) in comparison to adult DTC. Few studies suggested that the better response to RAI therapy in pediatric patients might be associated with an increased expression of NIS. However, a marked heterogeneity within the pediatric group has been recognized. Children (<10 years old) usually present a more aggressive disease than adolescents (>= 10-18 years old). By analyzing the expression of thyroid-specific genes in 38 sporadic pediatric tumors, we show that the expression of NIS, PDS, and TSHR was lower in children than adolescents (P < 0.05). A linear regression confirmed the association between NIS expression and age. Most significantly, NIS was expressed at similar levels in DTC from children and adults, whereas PDS and TSHR expression was even lower in DTC from children, compared to adolescents and adults. Our data suggest that biological behaviors of DTC in adolescents might differ from those in children and adults. Therefore, the premise that the expression of thyroid-specific genes is higher in tumors from pediatric patients than in adults is not entirely true and might be too oversimplified. (AU)

FAPESP's process: 12/02902-9 - The role of microRNAs in the regulation of C1orf24 expression in thyroid tumors
Grantee:Janete Maria Cerutti
Support type: Regular Research Grants
FAPESP's process: 13/03867-5 - Analysis of copy number variation (CNV) in pacientes of a family with men 2A and P.G533C mutation in the RET gene: identification of CNV regions associated with genesis and progression of medullary thyroid carcinoma
Grantee:Janete Maria Cerutti
Support type: Regular Research Grants