Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Causes, diagnosis, and treatment of central precocious puberty

Full text
Latronico, Ana Claudia [1] ; Brito, Vinicius Nahime [1] ; Carel, Jean-Claude [2, 3, 4, 5]
Total Authors: 3
[1] Univ Sao Paulo, Fac Med, Hosp Clin, Disciplina Endocrinol & Metabol, BR-05403900 Sao Paulo - Brazil
[2] Univ Paris Diderot, Sorbonne Paris Cite, Paris - France
[3] Hop Robert Debre, Dept Pediat Endocrinol & Diabetol, F-75019 Paris - France
[4] Ctr Reference Malad Endocriniennes Rares Croissan, Paris - France
[5] INSERM, U1141, Paris - France
Total Affiliations: 5
Document type: Journal article
Source: LANCET DIABETES & ENDOCRINOLOGY; v. 4, n. 3, p. 265-274, MAR 2016.
Web of Science Citations: 55

Central precocious puberty results from the premature activation of the hypothalamic-pituitary-gonadal axis. It mimics physiological pubertal development, although at an inappropriate chronological age (before 8 years in girls and 9 years in boys). It can be attributable to cerebral congenital malformations or acquired insults, but the cause in most cases in girls remains unknown. MKRN3 gene defects have been identified in familial disease, with important basic and clinical results. Indeed, genetic analysis of this gene should be included in the routine clinical investigation of familial and idiopathic cases of central precocious puberty. Gonadotropin-releasing hormone agonists are the gold-standard treatment. The assessment and management of this disease remain challenging for paediatric endocrinologists. In this Series paper, we describe current challenges involving the precise diagnosis and adequate treatment of this disorder. (AU)

FAPESP's process: 13/03236-5 - New approaches and methodologies in molecular-genetic studies of growth and pubertal development disorders
Grantee:Alexander Augusto de Lima Jorge
Support type: Research Projects - Thematic Grants