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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure

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Gomes, Mariana Janini [1] ; Martinez, Paula Felippe [1] ; Salome Campos, Dijon Henrique [1] ; Pagan, Luana Urbano [1] ; Bonomo, Camila [1] ; Ruiz Lima, Aline Regina [1] ; Damatto, Ricardo Luiz [1] ; Cezar, Marcelo D. M. [1] ; Damatto, Felipe Cezar [1] ; Rosa, Camila Moreno [1] ; Garcia, Camila Marchiolli [1] ; Abreu Reyes, David Rafael [1] ; Henrique Fernandes, Ana Angelica [2] ; Fernandes, Denise Castro [3] ; Laurindo, Francisco Rafael [3] ; Okoshi, Katashi [1] ; Okoshi, Marina Politi [1]
Total Authors: 17
[1] Sao Paulo State Univ UNESP, Botucatu Med Sch, Dept Internal Med, Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Inst Biosci Botucatu, Botucatu, SP - Brazil
[3] Univ Sao Paulo, Sch Med, Inst Heart, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Web of Science Citations: 22

Objective. We evaluated the influence of exercise on functional capacity, cardiac remodeling, and skeletal muscle oxidative stress, MAPK, and NF-kappa B pathway in rats with aortic stenosis-(AS-) induced heart failure (HF). Methods and Results. Eighteen weeks after AS induction, rats were assigned into sedentary control (C-Sed), exercised control (C-Ex), sedentary AS (AS-Sed), and exercised AS (AS-Ex) groups. Exercise was performed on treadmill for eight weeks. Statistical analyses were performed with Goodman and ANOVA or Mann-Whitney. HF features frequency and mortality did not differ between AS groups. Exercise improved functional capacity, assessed by maximal exercise test on treadmill, without changing echocardiographic parameters. Soleus cross-sectional areas did not differ between groups. Lipid hydroperoxide concentration was higher in AS-Sed than C-Sed and AS-Ex. Activity of antioxidant enzymes superoxide dismutase and glutathione peroxidase was changed in AS-Sed and restored in AS-Ex. NADPH oxidase activity and gene expression of its subunits did not differ between AS groups. Total ROS generation was lower in AS-Ex than C-Ex. Exercise modulated MAPK in AS-Ex and did not change NF-kappa B pathway proteins. Conclusion. Exercise improves functional capacity in rats with AS-induced HF regardless of echocardiographic parameter changes. In soleus, exercise reduces oxidative stress, preserves antioxidant enzyme activity, and modulates MAPK expression. (AU)

FAPESP's process: 12/21687-1 - Influence of N-acetylcysteine on apoptosis signaling in skeletal muscle of rats with chronic heart failure
Grantee:Marina Politi Okoshi
Support type: Regular Research Grants
FAPESP's process: 12/22485-3 - Influence of physical exercise on oxidative stress and protein expression of MAPK and NF-ºB pathways in soleus muscle of rats with aortic stenosis-induced heart failure
Grantee:Mariana Janini Gomes
Support type: Scholarships in Brazil - Master