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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

u HNdb: an integrated database of gene and protein information on head and neck squamous cell carcinoma

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Henrique, Tiago [1] ; Freitas da Silveira, Nelson Jose [2] ; Cunha Volpato, Arthur Henrique [1] ; Mioto, Mayra Mataruco [3] ; Buzzo Stefanini, Ana Carolina [1, 4] ; Fares, Adil Bachir [1] ; da Silva Castro Andrade, Joao Gustavo [1] ; Masson, Carolina [1] ; Mendoza Lopez, Rossana Veronica [5] ; Nunes, Fabio Daumas [6] ; Kowalski, Luis Paulo [7] ; Severino, Patricia [8] ; Tajara, Eloiza Helena [4, 1]
Total Authors: 13
[1] Sch Med Sao Jose do Rio Preto, Dept Mol Biol, Av Brigadeiro Faria Lima 5416 Vila Sao Pedro, BR-15090000 Sao Jose Do Rio Preto, SP - Brazil
[2] Univ Fed Alfenas, Inst Exact Sci, Rua Gabriel Monteiro Silva, 700 Ctr, BR-37130000 Alfenas, MG - Brazil
[3] Sch Med Sao Jose do Rio Preto, Dept Dermatol Infect & Parasit Dis, Av Brigadeiro Faria Lima 5416 Vila Sao Pedro, BR-15090000 Sao Jose do Rio Preto, SP - Brazil
[4] Univ Sao Paulo, Inst Biosci, Dept Genet & Evolutionary Biol, BR-05508090 Sao Paulo, SP - Brazil
[5] State Sao Paulo Canc Inst ICESP, Av Dr Arnaldo 251, BR-01246000 Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Sch Dent, Dept Stomatol, Ave Prof Lineu Prestes 2227, BR-05508000 Sao Paulo, SP - Brazil
[7] Canc Hosp AC Camargo, Dept Head & Neck Surg & Otorhinolaryngol, Rua Prof Antonio Prudente 211, BR-01509010 Sao Paulo, SP - Brazil
[8] Hosp Israelita Albert Einstein, Albert Einstein Res & Educ Inst, Av Albert Einstein 627, BR-05652000 Sao Paulo, SP - Brazil
Total Affiliations: 8
Document type: Journal article
Web of Science Citations: 3

The total amount of scientific literature has grown rapidly in recent years. Specifically, there are several million citations in the field of cancer. This makes it difficult, if not impossible, to manually retrieve relevant information on the mechanisms that govern tumor behavior or the neoplastic process. Furthermore, cancer is a complex disease or, more accurately, a set of diseases. The heterogeneity that permeates many tumors is particularly evident in head and neck (HN) cancer, one of the most common types of cancer worldwide. In this study, we present HNdb, a free database that aims to provide a unified and comprehensive resource of information on genes and proteins involved in HN squamous cell carcinoma, covering data on genomics, transcriptomics, proteomics, literature citations and also cross-references of external databases. Different literature searches of MEDLINE abstracts were performed using specific Medical Subject Headings (MeSH terms) for oral, oropharyngeal, hypopharyngeal and laryngeal squamous cell carcinomas. A curated gene-to-publication assignment yielded a total of 1370 genes related to HN cancer. The diversity of results allowed identifying novel and mostly unexplored gene associations, revealing, for example, that processes linked to response to steroid hormone stimulus are significantly enriched in genes related to HN carcinomas. Thus, our database expands the possibilities for gene networks investigation, providing potential hypothesis to be tested. Database URL: (AU)

FAPESP's process: 10/51168-0 - Environmental, clinical, histopathological and molecular factors associated with development and prognosis of head and neck squamous cell carcinomas
Grantee:Eloiza Helena Tajara da Silva
Support type: Research Projects - Thematic Grants