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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Up-regulation of Proinflammatory Genes and Cytokines Induced by S100A8 in CD8(+) T Cells in Lichen Planus

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Costa de Carvalho, Gabriel [1] ; Domingues, Rosana [1] ; Almeida de Sousa Nogueira, Marcelle [1] ; Calvielli Castelo Branco, Anna C. [1] ; Gomes Manfrere, Kelly C. [1] ; Vieira Pereira, Naiura [1] ; Aoki, Valeria [1] ; Nacagami Sotto, Mirian [1] ; da Silva Duarte, Alberto J. [1] ; Notomi Sato, Maria [1]
Total Authors: 10
[1] Univ Sao Paulo, Sch Med, Lab Dermatol & Immunodeficiency LIM 56, Dept Dermatol, BR-05403002 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: ACTA DERMATO-VENEREOLOGICA; v. 96, n. 4, p. 485-489, 2016.
Web of Science Citations: 5

Lichen planus (LP) is a chronic inflammatory mucocutaneous disease. The inflammatory status of LP may be related to S100A8 (myeloid-related protein 8; MRP8) activation of cytotoxic cells. The aims of this study were to evaluate S100A8 expression in skin lesions and the in vitro effects of S100A8 on CD8(+) T cells and natural killer (NK) cells in LP. Increased levels of S100A8/S100A9 were detected in the skin lesions as well as in the sera of subjects with LP. S100A8 expression induced an increased cytotoxic response by peripheral blood CD8(+)CD107a(+) T cells as well as by NK CD56(bright) cells in patients with LP. Increased expression of interleukin (1L)-1 beta, tumour necrosis factor (TNF) and IL-6 in the CD8(+) T cells of patients with LP was induced by S100A8, in contrast to the control group that produced IL- 10 and interferon type I genes. These data suggest that, in individuals with LP, S100A8 may exert distinct immunomodulatory and cytotoxicity functions. (AU)

FAPESP's process: 11/20740-3 - Evaluation of phenotypic and functional profile of myeloid and plasmocytoid dendritic cells and TCD4+ and TCD8+ cells in lichen planus
Grantee:Maria Notomi Sato
Support Opportunities: Regular Research Grants