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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Singlet molecular oxygen: Dusseldorf - Sao Paulo, the Brazilian connection

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Author(s):
Di Mascio, Paolo [1] ; Martinez, Glaucia R. [2] ; Miyamoto, Sayuri [1] ; Ronsein, Graziella E. [1] ; Medeiros, Marisa H. G. [1] ; Cadet, Jean [3, 4]
Total Authors: 6
Affiliation:
[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, CP 26077, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Fed Parana, Dept Bioquim & Biol Mol, Setor Ciencias Biol, BR-81531990 Curitiba, PR - Brazil
[3] Univ Sherbrooke, Sherbrooke, PQ J1H 5N4 - Canada
[4] CEA, INAC, F-38000 Grenoble - France
Total Affiliations: 4
Document type: Journal article
Source: Archives of Biochemistry and Biophysics; v. 595, n. SI, p. 161-175, APR 2 2016.
Web of Science Citations: 5
Abstract

Inspired by Helmut Sies we continue the development of suitable chemical generators of O-1(2) based on the thermodissociation of naphthalene endoperoxide derivatives. The present manuscript focuses on how the use of {[}O-18] -labeled endoperoxides and hydroperoxides can be applied to study mechanistic aspects related to the generation of singlet molecular oxygen and its reactions in biological systems. The peroxidation reactions of the main cellular targets including unsaturated lipids, proteins and nucleic acids have received major attention during the last three decades. Emphasis is placed in this manuscript on the description of the synthesis and the main use of {[}O-18]-labeled compounds, and especially of peroxides and O-1(2), for tracer elucidation of reaction mechanisms. (C) 2015 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 12/12663-1 - Singlet molecular oxygen and peroxides in chemical biology
Grantee:Paolo Di Mascio
Support type: Research Projects - Thematic Grants
FAPESP's process: 11/10048-5 - Mapping adducts generated by endogenous and exogenous aldehydes: use as biomarkers of redox stress
Grantee:Marisa Helena Gennari de Medeiros
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/07937-8 - Redoxome - Redox Processes in Biomedicine
Grantee:Ohara Augusto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC