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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Control of Stress-Induced ACTH Secretion by Vasopressin and CRH: Additional Evidence

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Ramos, Adriana T. [1, 2, 3] ; Tufik, Sergio [1] ; Troncone, Lanfranco R. P. [2]
Total Authors: 3
[1] Univ Fed Sao Paulo, Dept Psychobiol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Inst Butantan, Pharmacol Lab, Sao Paulo - Brazil
[3] Univ Sao Paulo, Inst Biomed Sci, Lab Mol Neuropharmacol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: NEUROPSYCHOBIOLOGY; v. 73, n. 3, p. 184-190, 2016.
Web of Science Citations: 2

Vasopressin and CRH have complementary roles in the secretion of ACTH following different stress modalities. The concomitant use of V-1b and CRF1 receptor antagonists completely inhibits ACTH secretion in response to different stress modalities. The combination of the CRF1 antagonist SSR125543 with the V-1b antagonist SSR149415 effectively suppressed plasma ACTH 1.30 h after injection in rats stressed by ether vapor inhalation for 1 min, restraint stress for 1 h or forced swimming for 5 min. The duration of the effect was also studied. The CRF1 antagonist effectively suppressed ACTH secretion in restraint stress, while the V-1b antagonist was effective against ether inhalation. Both antagonists were necessary to block the forced swimming stress response. SSR125543 induced a prolonged effect and can be used in a model of prolonged HPA axis blockade. (C) 2016 S. Karger AG, Basel (AU)

FAPESP's process: 98/14303-3 - Center for Sleep Studies
Grantee:Sergio Tufik
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 13/18897-7 - Contribution to antidepressive drug development
Grantee:Lanfranco Ranieri Paolo Troncone
Support type: Regular Research Grants
FAPESP's process: 15/08098-5 - Improvements on the unpredictable chronic mild stress (UCMS) model for anti-depressive testing
Grantee:Adriana de Toledo Ramos
Support type: Scholarships in Brazil - Post-Doctorate