Advanced search
Start date
Betweenand
Related content
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Frontal Lobe Degeneration in Adults with Down Syndrome and Alzheimer's Disease: A Review

Full text
Author(s):
Fonseca, Luciana Mascarenhas [1] ; Yokomizo, Juliana Emy [1] ; Bottino, Cassio Machado [1] ; Fuentes, Daniel [2]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Med, Old Age Res Grp PROTER, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Integrated Labs Neuropsychol LINEU, Dept Psychiat, Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS; v. 41, n. 3-4, p. 123-136, 2016.
Web of Science Citations: 5
Abstract

Background: There is a proven link between Down syndrome and the early development of the neuropathological features of Alzheimer's disease (AD). Changes in the personality and behavior of adults with Down syndrome might indicate the early stages of dementia or of frontotemporal lobar degeneration. The objective of this study was to investigate the executive functions and changes in behavior associated with frontal lobe degeneration in individuals with Down syndrome who develop AD. We conducted a systematic review selecting studies employing cognitive assessments. Summary: We identified few studies using objective measurements to determine whether cognitive aspects associated with the frontal lobe correlate with dementia in this population. We observed a tendency toward such correlations. (C) 2016 S. Karger AG, Basel (AU)

FAPESP's process: 13/11571-9 - Risk factors for dementia and cognitive decline in adults with Down Syndrome and the CAMDEX-DS validation
Grantee:Luciana Mascarenhas Fonseca
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)