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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Aqueous leaf extract of Passiflora alata Curtis promotes antioxidant and anti-inflammatory effects and consequently preservation of NOD mice beta cells (non-obese diabetic)

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Author(s):
Figueiredo, D. [1] ; Colomeu, Talita Cristina [1] ; Gonzalez Schumacher, Nayara Simon [1] ; Stivanin-Silva, L. G. [1] ; Betim Cazarin, Cinthia Bau [2] ; Molina Meletti, Laura Maria [3] ; Romani Fernandes, Luis Gustavo [1] ; Prado, Marcelo Alexandre [2] ; Zollner, R. L. [1, 4]
Total Authors: 9
Affiliation:
[1] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Lab Translat Immunol, Rua Vital Brasil 300, Cidade Univ Zeferino Vaz, BR-13083887 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Sch Food Engn, Dept Food & Nutr, Rua Monteiro Lobato 80, Cidade Univ Zeferino Vaz, BR-13083862 Campinas, SP - Brazil
[3] Agron Inst Campinas, Av Theodureto de Almeida Camargo 1500, BR-13012970 Campinas, SP - Brazil
[4] Univ Estadual Campinas, Fac Med Sci, Dept Internal Med, Rua Alexandre Fleming 09, Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: International Immunopharmacology; v. 35, p. 127-136, JUN 2016.
Web of Science Citations: 5
Abstract

Passiflora alata Curtis (P. alata) leaves have anti-inflammatory properties; the present study aimed to investigate the anti-diabetogenic properties of P. alata aqueous leaf extract. HPLC analysis identified the phenolic compounds catechin, epicatechin and rutin. The aqueous extract was administered for 30 weeks to non-obese diabetic (NOD) mice presenting a decrease of 28.6% in diabetes incidence and the number of inflammatory cells in pancreatic islets, when compared with the control group (water). The P. alata group presented an antioxidant effect and decreased lipid peroxidation in the serum of NOD mice. Increased numbers of insulin-positive cells were also observed in the pancreatic islets of the treated group. The diabetic group exhibited higher levels in the glucose tolerance test and glycemic index, in comparison to the P. alata-treated group and non-diabetic control BALB/c mice. In addition, the P. alata extract reduced the percentage and the proliferation index of NOD mice lymphocytes submitted to in vitro dose/response mitogenic stimulation assays. These results suggest that the aqueous extract of P. alata has anti-inflammatory properties, contributing to the protection of beta cells in pancreatic islets in NOD mice, and presents potential for use a supporting approach to treat type I diabetes. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/25256-8 - Anti-diabetogenic, antioxidant / antiinflammatory / antiapoptotic effects of aqueous extract of Passiflora alata and components vitexin, Isoorientin, rutin and catechin
Grantee:Ricardo de Lima Zollner
Support type: Regular Research Grants
FAPESP's process: 11/06559-4 - Identification and Characterization of compounds of the aqueous extract of Passiflora alata. Effect of treatment on diabetes expression and modulation of inflammation in pancreatic islets in the NOD mouse model of type 1 diabetes (non-obese diabetic)
Grantee:Ricardo de Lima Zollner
Support type: Regular Research Grants
FAPESP's process: 11/15763-4 - Expression of dependent-cyclin kinase (Cdks 1, 2, 4 e 6) on pancreatic islets of NOD mouse (non-obese diabetic) treated with leaves aqueous extract of Passiflora alata
Grantee:Daniella de Figueiredo
Support type: Scholarships in Brazil - Master