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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Bioactive CaCO3/poly(acrylic acid)/chitosan hybrid coatings deposited on titanium

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Cruz, Marcos Antonio E. [1] ; Ramos, Ana P. [1]
Total Authors: 2
[1] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040901 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: SURFACE & COATINGS TECHNOLOGY; v. 294, p. 145-152, MAY 25 2016.
Web of Science Citations: 6

Modifying metallic surfaces is a useful strategy to improve interactions between implant and the host-tissue interface and consequently achieve better osteointegration of the implanted material. This work reports on titanium (Ti) surfaces modified with a biomimetic hydroxyapatite (HAp) grown on a hybrid CaCO3 film. A layer-by layer (LbL) organic matrix consisting of poly(acrylic acid) (PAA) and chitosan (Cht) served as template for biomineral growth. Infrared spectroscopy, optical microscopy, and zeta potential analysis aided evaluation of the organic matrix properties upon changes in Ca2+ concentration during multilayers formation. At the highest Ca2+ concentration, Ca+ completely replaced H+ in the PM carboxylate groups in both the polymer solution and the solution used during the washing step. In the selected conditions, zeta-potential analysis did not show any overcompensation phenomenon, so hydrogen bonding must have driven film growth. Deposition of PAA/Cht films containing Ca2+ ions on Ti surfaces promoted CaCO3 growth after exposure to CO2(g). After deposition, immersion of the films in simulated body fluid (SBF) at 37 degrees C for 48 h elicited HAp growth. Scanning electron microscopy, infrared spectroscopy, X-ray diffraction, and contact angle measurements were used to characterize the resulting hybrid films. Ti modified with the hybrid coating afforded a bioactive surface with high surface free energy and wettability, which constituted optimized characteristics for biomedical applications. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/22689-8 - Modification of metallic surfaces with Langmuir-Blodgett and self-assembled polymeric films containing calcium carbonate aiming application as osteoinductive systems
Grantee:Marcos Antonio Eufrásio Cruz
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/20946-3 - Study of the growth of calcium phosphates and carbonates on organic matrices deposited on mettalic supports: obtainment of osteoinductive biomaterials
Grantee:Ana Paula Ramos
Support Opportunities: Regular Research Grants