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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of Aluminum Ion Incorporation on the Bioactivity and Structure in Mesoporous Bioactive Glasses

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Melchers, S. [1] ; Uesbeck, T. [1] ; Winter, O. [1, 2] ; Eckert, H. [1, 3] ; Eder, D. [1, 2]
Total Authors: 5
[1] Univ Munster, Inst Phys Chem, Corrensstr 28-30, D-48149 Munster - Germany
[2] Vienna Univ Technol, Inst Mat Chem, Getreidemkt 9-BC-02, A-1060 Vienna - Austria
[3] Univ Sao Paulo, Inst Fis Sao Carlos, CEP 369, BR-13560590 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Chemistry of Materials; v. 28, n. 10, p. 3254-3264, MAY 24 2016.
Web of Science Citations: 10

work is dedicated to biokinetic and structural investigations of Al2O3 doping (0.5 to 15 mol %) in ordered mesoporous bioactive glasses (MBGs), based on the composition 80% SiO2-15% CaO-5% P2O5 (in mol %). The synthesis was performed with the sol gel method in combination with a structure directing agent (P-123) for the formation of mesopores. Structural investigations reveal that the incorporation of additional Al2O3 in a range of 1 to 10 mol % reduces the order of the mesostructure, whereas doping with 15 mol % Al2O3 creates well ordered mesopores again. Nitrogen adsorption-desorption isotherms show that specific surface area, pore volume, and pore diameter decrease only slightly upon incorporation of Al2O3. In vitro bioactivity tests exhibit a small decrease in bioactivity upon incorporation of small amounts and a sudden drop beyond 3 mol %. This can be related to the strong interaction of Al3+ and PO43-, which could be proven by multinuclear single and double resonance solid state nuclear magnetic resonance (NMR) spectroscopy. The number of P-O-Al linkages has been estimated by Al-27(P-31) rotational echo double resonance (REDOR) experiments. The interaction of Al3+ and PO43- and the trapping of Ca2+ required for charge compensation hamper the release of P, Ca, and Si ions and thus provide less PO43- and Ca2+ ions for the crucial formation of hydroxycarbonate apatite (HCA). (AU)

FAPESP's process: 13/07793-6 - CEPIV - Center for Teaching, Research and Innovation in Glass
Grantee:Edgar Dutra Zanotto
Support type: Research Grants - Research, Innovation and Dissemination Centers - RIDC