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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Adrenal-Derived Hormones Differentially Modulate Intestinal Immunity in Experimental Colitis

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Author(s):
de Souza, Patricia Reis [1] ; Sales-Campos, Helioswilton [1] ; Basso, Paulo Jose [2] ; Nardini, Viviani [1] ; Silva, Angelica [1] ; Banquieri, Fernanda [1] ; Freitas Alves, Vanessa Beatriz [1] ; Lazo Chica, Javier Emilio [3] ; Nomizo, Auro [1] ; de Barros Cardoso, Cristina Ribeiro [1]
Total Authors: 10
Affiliation:
[1] Univ Sao Paulo, Dept Anal Clin Toxicol & Bromatol, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Bioquim & Imunol, Fac Med Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil
[3] Univ Fed Triangulo Mineiro, Inst Ciencias Biol & Nat, Uberaba, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Mediators of Inflammation; 2016.
Web of Science Citations: 1
Abstract

The adrenal glands are able to modulate immune responses through neuroimmunoendocrine interactions and cortisol secretion that could suppress exacerbated inflammation such as in inflammatory bowel disease (IBD). Therefore, here we evaluated the role of these glands in experimental colitis induced by 3% dextran sulfate sodium (DSS) in C57BL/6 mice subjected to adrenalectomy, with or without glucocorticoid (GC) replacement. Mice succumbed to colitis without adrenals with a higher clinical score and augmented systemic levels of IL-6 and lower LPS. Furthermore, adrenalectomy negatively modulated systemic regulatory markers. The absence of adrenals resulted in augmented tolerogenic lamina propria dendritic cells but no compensatory local production of corticosterone and decreased mucosal inflammation associated with increased IFN-gamma. and FasL in the intestine. To clarify the importance of GC in this scenario, GC replacement in adrenalectomized mice restored different markers to the same degree of that observed in DSS group. Finally, this is the first time that adrenal-derived hormones, especially GC, were associated with the differential local modulation of the gut infiltrate, also pointing to a relationship between adrenalectomy and the modulation of systemic regulatory markers. These findings may elucidate some neuroimmunoendocrine mechanisms that dictate colitis outcome. (AU)

FAPESP's process: 12/00984-8 - Participation of hypothalamus-pituitary-adrenal axis in experimental induced inflammatory bowel disease
Grantee:Patrícia Reis de Souza
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 10/20162-7 - The role of hypothalamus-pituitary-adrenal (HPA) axis and exogenous glucocorticoids in the modulation of immune response in inflammatory bowel disease
Grantee:Cristina Ribeiro de Barros Cardoso
Support type: Research Grants - Young Investigators Grants