| Full text | |
| Author(s): Show less - |
Pereira, Paulo Rogerio
[1]
;
Oliveira-Junior, Manoel Carneiro
[1]
;
Mackenzie, Breanne
[1]
;
Davino Chiovatto, Jaime Eduardo
[1]
;
Matos, Yves
[1]
;
Greiffo, Flavia Regina
[1]
;
Rigonato-Oliveira, Nicole Cristine
[1]
;
Brugemman, Thayse Regina
[2]
;
Delle, Humberto
[1]
;
Idzko, Marco
[3]
;
Albertini, Regiane
[1]
;
Ligeiro Oliveira, Ana Paula
[1]
;
Damaceno-Rodrigues, Nilsa Regina
[4]
;
Caldini, Elia Garcia
[4]
;
Fernandez, Isis Ensil
[5]
;
Castro-Faria-Neto, Hugo Caire
[6]
;
Dolhnikoff, Marisa
[7]
;
Eickelberg, Oliver
[5]
;
Vieira, Rodolfo Paula
[1]
Total Authors: 19
|
| Affiliation: | [1] Nove de Julho Univ, Lab Pulm & Exercise Immunol, Sao Paulo - Brazil
[2] Univ Sao Paulo, Sch Med, Lab Expt Therapeut, Sao Paulo - Brazil
[3] Univ Hosp Freiburg, Dept Pneumol, COPD & Asthma Res Grp, Freiburg - Germany
[4] Univ Sao Paulo, Sch Med, Lab Cellular Biol, Sao Paulo - Brazil
[5] Univ Munich, Univ Hosp, Comprehens Pneumol Ctr, Munich - Germany
[6] Fundacao Oswaldo Cruz, Inst Oswaldo Cruz, Lab Immunopharmacol, Rio De Janeiro - Brazil
[7] Univ Sao Paulo, Sch Med, Dept Pathol, Lab Expt Air Pollut, Sao Paulo - Brazil
Total Affiliations: 7
|
| Document type: | Journal article |
| Source: | MEDICINE AND SCIENCE IN SPORTS AND EXERCISE; v. 48, n. 7, p. 1276-1284, JUL 2016. |
| Web of Science Citations: | 11 |
| Abstract | |
Purpose: Idiopathic pulmonary fibrosis (IPF) is a chronic fibrosing interstitial pneumonia, which involves aberrant serotonin (5-hydroxytryptamine {[}5-HT]) and Akt signaling. As protective effects of chronic aerobic training (AT) have been demonstrated in the context of lung injury, this study investigated whether AT attenuates bleomycin-induced lung fibrosis partly via a reduction of 5-HT and AKT signaling. Methods: Seventy-two C57BL/6 male mice were distributed in Control (Co), Exercise (Ex), Fibrosis (Fi), and Fibrosis + Exercise (Fi + Ex) groups. Bleomycin (1.5 UI.kg(-1)) was administered on day 1 and treadmill AT began on day 15 and continued for 60 min.d(-1), 5 d.wk(-1) for 4 wk. We evaluated total and differential cell counts in bronchoalveolar lavage (BAL), interleukin (IL)-1A, IL-6, CXCL1/KC, IL-10, tumor necrosis factor alpha, and transforming growth factor A levels in BAL, collagen content in lung parenchyma, 5-HT levels in BAL fluid and in serum, the expression of 5-HT2B receptor, and Akt phosphorylation in lung tissue. Results: AT reduced bleomycin-increased number of total cells (P < 0.001), neutrophils (P < 0.01), macrophages (P < 0.01), and lymphocytes (P < 0.05) in BAL. It also reduced the levels of IL-1A (P < 0.01), IL-6 (P < 0.05), CXCL1/KC (P < 0.001), tumor necrosis factor > (P < 0.001), and transforming growth factor A (P < 0.001). It increased expression of ant-inflammatory cytokine IL-10 (P < 0.001). It reduced bleomycin-increased 5-HT levels in BAL (P < 0.001) and in serum (P < 0.05). Reductions in collagen fiber deposition (P < 0.01), 5-HT2B receptor expression (P < 0.01), and Akt phosphorylation in lung tissue were observed. Conclusions: AT accelerates the resolution of lung inflammation and fibrosis in a model of bleomycin-induced lung fibrosis partly via attenuation of 5-HT/Akt signaling. (AU) | |
| FAPESP's process: | 14/23196-0 - The role of purinergic signalling and of SOCS-JAK-STAT signalling in the anti-inflammatory effects of aerobic training in asthmatic individuals. |
| Grantee: | Breanne Mackenzie |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 14/14604-8 - Role of purinergic signaling in the antiinflammatory effects of aerobic training in a model of asthma induced by house dust mite |
| Grantee: | Manoel Carneiro de Oliveira Junior |
| Support type: | Scholarships in Brazil - Doctorate |
| FAPESP's process: | 12/51464-4 - Effects of aerobic exercise on pulmonary fibrosis induced by bleomycin |
| Grantee: | Rodolfo de Paula Vieira |
| Support type: | Regular Research Grants |
| FAPESP's process: | 12/15165-2 - Role of purinergic signaling and of SOCS-JAK-STAT signaling in the antiinflammatory effects of aerobic training in experimental models of asma and in asthmatic individuals |
| Grantee: | Rodolfo de Paula Vieira |
| Support type: | Research Grants - Young Investigators Grants |