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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A fast method for bisphenol A and six analogues (S, F, Z, P, AF, AP) determination in urine samples based on dispersive liquid-liquid microextraction and liquid chromatography-tandem mass spectrometry

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Author(s):
Rocha, Bruno Alves [1] ; Brandao da Costa, Bruno Ruiz [1] ; Perez de Albuquerque, Nayara Cristina [2] ; Moraes de Oliveira, Anderson Rodrigo [2] ; Oliveira Souza, Juliana Maria [1] ; Al-Tameemi, Maha [3] ; Campiglia, Andres Dobal [3] ; Barbosa, Jr., Fernando [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Lab Toxicol & Essencialidade Metais, Fac Ciencias Farmaceut Ribeirao Preto, Ave Cafe S-N, BR-14049903 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14049901 Ribeirao Preto, SP - Brazil
[3] Univ Cent Florida, Dept Chem, Orlando, FL 32816 - USA
Total Affiliations: 3
Document type: Journal article
Source: Talanta; v. 154, p. 511-519, JUL 1 2016.
Web of Science Citations: 39
Abstract

In this study, a novel method combining dispersive liquid-liquid microextraction (DLLME) and fast liquid chromatography coupled to mass spectrometry (LC-MS/MS) was developed and validated for the extraction and determination of bisphenol A (BPA) and six bisphenol analogues, namely bisphenol S (BPS), bisphenol F (BPF), bisphenol P (BPP), bisphenol Z (BPZ), bisphenol AP (BPAP) and bisphenol AF (BPAF) in human urine samples. Type and volume of extraction and disperser solvents, pH sample, ionic strength, and agitation were evaluated. The matrix -matched calibration curves of all analytes were linear with correlation coefficients higher than 0.99 in the range level of 0.5-20.0 ng The relative standard deviation (RSD), precision, at three concentrations (1.0, 8.0 and 15.0 ng mL(-1)) was lower than 15% with accuracy ranging from 90 to 112%. The biomonitoring capability of the new method was confirmed with the analysis of 50 human urine samples randomly collected from Brazilians. BPA was detected in 92% of the analyzed samples at concentrations ranging < LOQ to 10.4 ng mL(-1). The detection rates of BPS (10%), BPAF (4%) and BPF (2%) were much lower than 92%. (C) 2016 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 13/23710-3 - The use of Shpol'skii spectroscopy and LC-MS/MS for determination of bisphenol A and analogues in urine samples and exposure assessment in children living in the São Paulo State, Brazil
Grantee:Bruno Alves Rocha
Support Opportunities: Scholarships in Brazil - Post-Doctoral