| Full text | |
| Author(s): |
Dantonio, Valter
[1, 2]
;
Batalhao, Marcelo E.
[3]
;
Fernandes, Marcia H. M. R.
[4]
;
Komegae, Evilin N.
[5]
;
Buqui, Gabriela A.
[6]
;
Lopes, Norberto P.
[6]
;
Gargaglioni, Luciane H.
[1, 2]
;
Carnio, Evelin C.
[3]
;
Steiner, Alexandre A.
[5]
;
Bicego, Kenia C.
[1, 2]
Total Authors: 10
|
| Affiliation: | [1] Sao Paulo State Univ, Dept Anim Morphol & Physiol, Coll Agr & Vet Sci, Sao Paulo - Brazil
[2] Natl Inst Sci & Technol Comparat Physiol INCT Fis, Sao Paulo - Brazil
[3] Univ Sao Paulo, Nursing Sch Ribeirao Preto, Sao Paulo - Brazil
[4] Sao Paulo State Univ, Dept Anim Sci, Coll Agr & Vet Sci, Sao Paulo - Brazil
[5] Univ Sao Paulo, Inst Biomed Sci, Dept Immunol, Sao Paulo, SP - Brazil
[6] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Chem & Phys, Nucleo Pesquisa Prod Nat & Sintet, Sao Paulo - Brazil
Total Affiliations: 6
|
| Document type: | Journal article |
| Source: | AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY; v. 310, n. 10, p. R896-R905, MAY 15 2016. |
| Web of Science Citations: | 3 |
| Abstract | |
Nitric oxide (NO) plays a role in thermogenesis but does not mediate immune-to-brain febrigenic signaling in rats. There are suggestions of a different situation in birds, but the underlying evidence is not compelling. The present study was designed to clarify this matter in 5-day-old chicks challenged with a low or high dose of bacterial LPS. The lower LPS dose (2 mu g/kg im) induced fever at 3-5 h postinjection, whereas 100 mu g/kg im decreased core body temperature (T-c) (at 1 h) followed by fever (at 4 or 5 h). Plasma nitrate levels increased 4 h after LPS injection, but they were not correlated with the magnitude of fever. The NO synthase inhibitor (NG-nitro-L-arginine methyl ester, L-NAME; 50 mg/kg im) attenuated the fever induced by either dose of LPS and enhanced the magnitude of the Tc reduction induced by the high dose in chicks at 31-32 degrees C. These effects were associated with suppression of metabolic rate, at least in the case of the high LPS dose. Conversely, the effects of L-NAME on Tc disappeared in chicks maintained at 35-36 degrees C, suggesting that febrigenic signaling was essentially unaffected. Accordingly, the LPS-induced rise in the brain level of PGE(2) was not affected by L-NAME. Moreover, L-NAME augmented LPS-induced huddling, which is indicative of compensatory mechanisms to run fever in the face of attenuated thermogenesis. Therefore, as in rats, systemic inhibition of NO synthesis attenuates LPS-induced fever in chicks by affecting thermoeffector activity and not by interfering with immune-to-brain signaling. This may constitute a conserved effect of NO in endotherms. (AU) | |
| FAPESP's process: | 14/13586-6 - Effect on ghrelin on growth hormone/insuline-like growth factor in rats submmited to endotoxemia |
| Grantee: | Evelin Capellari Cárnio |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/19966-0 - Cardiorespiratory pattern and awake-sleep state in male and female rats exposed to fluoxetine during prenatal period |
| Grantee: | Luciane Helena Gargaglioni Batalhão |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 13/13386-4 - Putative role of nitric oxide and greline as mediators/modulators of the febrile response in broiler chicks |
| Grantee: | Kênia Cardoso Bícego |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 12/03831-8 - Linking energy balance to systemic inflammation: role of leptin |
| Grantee: | Alexandre Alarcon Steiner |
| Support Opportunities: | Research Grants - Young Investigators Grants |
| FAPESP's process: | 14/50265-3 - Distribution and metabolism of natural and synthetic xenobiotics: from the comprehension of reactional process to tissue imaging generation |
| Grantee: | Norberto Peporine Lopes |
| Support Opportunities: | BIOTA-FAPESP Program - Thematic Grants |