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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Mansonella ozzardi: a neglected New World filarial nematode

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Author(s):
Lima, Nathalia F. [1] ; Aybar, Cecilia A. Veggiani [2] ; Juri, Maria J. Dantur [2] ; Ferreira, Marcelo U. [1]
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Av Prof Lineu Prestes 1374, BR-05508900 Sao Paulo - Brazil
[2] Natl Univ Tucuman, Fac Nat Sci, San Miguel De Tucuman - Argentina
Total Affiliations: 2
Document type: Review article
Source: PATHOGENS AND GLOBAL HEALTH; v. 110, n. 3, p. 97-107, 2016.
Web of Science Citations: 6
Abstract

Mansonella ozzardi (Nematoda: Onchocercidae) is an understudied filarial nematode, originally described by Patrick Manson in 1897, that can be transmitted by two families of dipteran vectors, biting midges (most of them members of the genus Culicoides) and black flies (genus Simulium). With a patchy geographic distribution from southern Mexico to northwestern Argentina, human infection with M. ozzardi is highly prevalent in some of the Caribbean islands, along riverine communities in the Amazon Basin, and on both sides of the border between Bolivia and Argentina. There is no clinical entity unequivocally associated with M. ozzardi infection, although fever, arthralgia, headache, cold lower extremities, and itchy cutaneous rashes are occasionally mentioned in case report series. More recently, ocular manifestations (especially keratitis) have been associated with mansonelliasis, opening an important area of investigation. Here, we briefly review the biology, epidemiology, pathogenesis, and clinical aspects of M. ozzardi infection and point to some existing knowledge gaps, aiming to stimulate a research agenda to help filling them. (AU)

FAPESP's process: 13/26928-0 - Mansonella ozzardi: a neglected filaria that may modulate the immune response to co-occurring infections
Grantee:Nathália Ferreira Lima
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/12723-7 - Mansonella ozzardi: a neglected filaria that may modulate the immune response to co-occurring infections
Grantee:Marcelo Urbano Ferreira
Support Opportunities: Regular Research Grants