| Full text | |
| Author(s): Show less - |
Célio F. F. Angolini
[1]
;
Ana B. Gonçalves
[2]
;
Renata Sigrist
[3]
;
Bruno S. Paulo
[4]
;
Markiyan Samborskyy
[5]
;
Pedro L. R. Cruz
[6]
;
Adriana F. Vivian
[7]
;
Eduardo M. Schmidt
[8]
;
Marcos N. Eberlin
[9]
;
Welington L. Araújo
[10]
;
Luciana G. de Oliveira
[11]
Total Authors: 11
|
| Affiliation: Show less - | [1] Universidade Estadual de Campinas. Instituto de Química. Departamento de Química Orgânica - Brasil
[2] Universidade Estadual de Campinas. Instituto de Química. Departamento de Química Orgânica - Brasil
[3] Universidade Estadual de Campinas. Instituto de Química. Departamento de Química Orgânica - Brasil
[4] Universidade Estadual de Campinas. Instituto de Química. Departamento de Química Orgânica - Brasil
[5] University of Cambridge. Department of Biochemistry - Reino Unido
[6] Universidade Estadual de Campinas. Instituto de Química. Departamento de Química Orgânica - Brasil
[7] Universidade Estadual de Campinas. Faculdade de Ciências Farmacêuticas - Brasil
[8] Universidade Estadual de Campinas. Instituto de Química. Departamento de Química Orgânica - Brasil
[9] Universidade Estadual de Campinas. Instituto de Química. Departamento de Química Orgânica - Brasil
[10] Universidade de São Paulo. Instituto de Ciências Biomédicas. Departamento de Microbiologia - Brasil
[11] Universidade Estadual de Campinas. Instituto de Química. Departamento de Química Orgânica - Brasil
Total Affiliations: 11
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 27, n. 8, p. 1465-1475, 2016-08-00. |
| Abstract | |
The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which reveals several antibiotic biosynthetic pathways. Using mass spectrometry, we were able to identify desferoxamines, several antimycins and candicidin, as predicted. Additionally, it was possible to confirm that the biosynthetic machinery of the strain when compared to identified known metabolites is far underestimated. As suggested by biochemical qualitative tests, genome encoded information reveals that the strain A23 has high capability to produce antibiotics. (AU) | |
| FAPESP's process: | 14/12727-5 - Genome mining in Streptomyces |
| Grantee: | Luciana Gonzaga de Oliveira |
| Support Opportunities: | Regular Research Grants |
| FAPESP's process: | 15/01013-4 - Mining a t1PKS-transAT PKS-NRPS in Streptomyces sp. genome |
| Grantee: | Renata Sigrist |
| Support Opportunities: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 13/12598-8 - Mining a of t1PKS-transAT PKS-NRPS in Streptomyces sp. |
| Grantee: | Renata Sigrist |
| Support Opportunities: | Scholarships in Brazil - Master |
| FAPESP's process: | 10/51677-2 - Development of new mass spectrometry techniques and their general applications in science: chemistry, biochemistry, material sciences, forensics, medicine, food science, pharmaceutical and veterinary medicine |
| Grantee: | Marcos Nogueira Eberlin |
| Support Opportunities: | Research Projects - Thematic Grants |