| Full text | |
| Author(s): Show less - |
Célio F. F. Angolini
;
Ana B. Gonçalves
;
Renata Sigrist
;
Bruno S. Paulo
;
Markiyan Samborskyy
;
Pedro L. R. Cruz
;
Adriana F. Vivian
;
Eduardo M. Schmidt
;
Marcos N. Eberlin
;
Welington L. Araújo
;
Luciana G. de Oliveira
Total Authors: 11
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 27, n. 8, p. 1465-1475, Ago. 2016. |
| Abstract | |
The actinobacteria Streptomyces wadayamensis A23, an endophitic strain, was recently sequenced and previous work showed qualitatively that the strain inhibits the growth of some pathogens. Herein we report the genome analysis of S. wadayamensis which reveals several antibiotic biosynthetic pathways. Using mass spectrometry, we were able to identify desferoxamines, several antimycins and candicidin, as predicted. Additionally, it was possible to confirm that the biosynthetic machinery of the strain when compared to identified known metabolites is far underestimated. As suggested by biochemical qualitative tests, genome encoded information reveals that the strain A23 has high capability to produce antibiotics. (AU) | |
| FAPESP's process: | 13/12598-8 - Mining a of t1PKS-transAT PKS-NRPS in Streptomyces sp. |
| Grantee: | Renata Sigrist |
| Support type: | Scholarships in Brazil - Master |
| FAPESP's process: | 15/01013-4 - Mining a t1PKS-transAT PKS-NRPS in Streptomyces sp. genome |
| Grantee: | Renata Sigrist |
| Support type: | Scholarships in Brazil - Doctorate (Direct) |
| FAPESP's process: | 10/51677-2 - Development of new mass spectrometry techniques and their general applications in science: chemistry, biochemistry, material sciences, forensics, medicine, food science, pharmaceutical and veterinary medicine |
| Grantee: | Marcos Nogueira Eberlin |
| Support type: | Research Projects - Thematic Grants |
| FAPESP's process: | 14/12727-5 - Genome mining in Streptomyces |
| Grantee: | Luciana Gonzaga de Oliveira |
| Support type: | Regular Research Grants |